eprintid: 26343
rev_number: 13
eprint_status: archive
userid: 1589
dir: disk0/00/02/63/43
datestamp: 2019-06-18 11:38:43
lastmod: 2024-04-05 18:52:46
status_changed: 2019-06-18 11:38:43
type: article
metadata_visibility: show
creators_name: Baumann, Katrine Y.
creators_name: Church, Martin K.
creators_name: Clough, Geraldine F.
creators_name: Quist, Sven Roy
creators_name: Schmelz, Martin
creators_name: Skov, Per Stahl
creators_name: Anderson, Chris D.
creators_name: Tannert, Line Kring
creators_name: Giménez-Arnau, Ana Maria
creators_name: Frischbutter, Stefan
creators_name: Scheffel, Jörg
creators_name: Maurer, Marcus
title: Skin microdialysis: methods, applications and future opportunities — an EAACI position paper
subjects: ddc-610
divisions: i-63600
keywords: Microdialysis, Cutaneous, Inflammation, Interstitial, Dermal
abstract: Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive character, SMD can be applied in both clinical and preclinical settings. Despite being available since the 1990s, the technique has still not reached its full potential use as a tool to explore pathophysiological mechanisms of allergic and inflammatory reactions in the skin. Therefore, an EAACI Task Force on SMD was formed to disseminate knowledge about the technique and its many applications. This position paper from the task force provides an overview of the current use of SMD in the investigation of the pathogenesis of chronic inflammatory skin diseases, such as atopic dermatitis, chronic urticaria, psoriasis, and in studies of cutaneous events during type 1 hypersensitivity reactions. Furthermore, this paper covers drug hypersensitivity, UVB-induced- and neurogenic inflammation, and drug penetration investigated by SMD. The aim of this paper is to encourage the use of SMD and to make the technique easily accessible by providing an overview of methodology and applications, supported by standardized operating procedures for SMD in vivo and ex vivo.
date: 2019
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 166765540X
own_urn: urn:nbn:de:bsz:16-heidok-263437
language: eng
bibsort: BAUMANNKATSKINMICROD2019
full_text_status: public
publication: Clinical and translational allergy
volume: 9
number: 24
place_of_pub: London
pagerange: 1-13
issn: 2045-7022
citation:   Baumann, Katrine Y. ; Church, Martin K. ; Clough, Geraldine F. ; Quist, Sven Roy ; Schmelz, Martin ; Skov, Per Stahl ; Anderson, Chris D. ; Tannert, Line Kring ; Giménez-Arnau, Ana Maria ; Frischbutter, Stefan ; Scheffel, Jörg ; Maurer, Marcus  (2019) Skin microdialysis: methods, applications and future opportunities — an EAACI position paper.  Clinical and translational allergy, 9 (24).  pp. 1-13.  ISSN 2045-7022     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/26343/1/13601_2019_Article_262.pdf