TY  - JOUR
PB  - Biomed Central
Y1  - 2019///
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/26480/
A1  - Rusnak, Jonas
A1  - Behnes, Michael
A1  - Schupp, Tobias
A1  - Lang, Siegfried
A1  - Reiser, Linda
A1  - Taton, Gabriel
A1  - Bollow, Armin
A1  - Reichelt, Thomas
A1  - Ellguth, Dominik
A1  - Engelke, Niko
A1  - Ansari, Uzair
A1  - El-Battrawy, Ibrahim
A1  - Bertsch, Thomas
A1  - Nienaber, Christoph A.
A1  - Akin, Muharrem
A1  - Mashayekhi, Kambis
A1  - Weiß, Christel
A1  - Borggrefe, Martin
A1  - Akin, Ibrahim
SP  - 1
SN  - 1476-511X
AV  - public
ID  - heidok26480
JF  - Lipids in health and disease
VL  - 18
N2  - Objectives: The study sought to assess the impact of statin therapy on survival in patients presenting with ventricular tachyarrhythmias.   

Background: Data regarding the outcome of patients with statin therapy presenting with ventricular tachyarrhythmias is limited.   

Methods: A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) or fibrillation (VF) from 2002 to 2016. Patients with statin were compared to patients without statin therapy (non-statin). The primary prognostic endpoint was long-term all-cause death at 3?years. Uni- and multivariable Cox regression analyses were applied in propensity-score matched cohorts.   

Results: A total of 424 matched patients was included. The rates of VT and VF were similar in both groups (VT: statin 71% vs. non-statin 68%; VF: statin 29% vs. 32%; p?=?0.460). Statin therapy was associated with lower all-cause mortality at long-term follow-up (mortality rates 16% versus 33%; log rank, p?=?0.001; HR?=?0.438; 95% CI 0.290?0.663; p?=?0.001), irrespective of the underlying type of ventricular tachyarrhythmia (VT/VF), left ventricular ejection fraction (LVEF) >?35%, presence of an activated implantable cardioverter defibrillator (ICD), cardiogenic shock or cardiopulmonary resuscitation (CPR).   

Conclusion: Statin therapy is independently associated with lower long-term mortality in patients presenting with ventricular tachyarrhythmias on admission.  

Trial registration: Clinicaltrials.gov, NCT02982473  , 11/29/2016, Retrospectively registered.
EP  - 11
CY  - London
TI  - Statin therapy is associated with improved survival in patients with ventricular tachyarrhythmias
IS  - 119
ER  -