eprintid: 26516
rev_number: 12
eprint_status: archive
userid: 1589
dir: disk0/00/02/65/16
datestamp: 2019-08-06 14:40:53
lastmod: 2019-08-26 10:32:18
status_changed: 2019-08-06 14:40:53
type: article
metadata_visibility: show
creators_name: Dingerkus, Vita L. S.
creators_name: Munk, Marion R.
creators_name: Brinkmann, Max P.
creators_name: Freiberg, Florentina J.
creators_name: Heussen, Florian M. A.
creators_name: Kinzl, Stephan
creators_name: Lortz, Sandra
creators_name: Orgül, Selim
creators_name: Becker, Matthias
title: Optical coherence tomography angiography (OCTA) as a new diagnostic tool in uveitis
subjects: ddc-610
divisions: i-910900
keywords: Optical coherence tomography angiography, Fluorescein angiography, Indocyanine angiography, Uveitis, Diagnostic tools
abstract: Background: The broad spectrum of uveitis disorders requires a multimodal imaging approach in the daily practice of an ophthalmologist. As inflammatory conditions, they have in common an alteration in leukocyte migration. In this context, optical coherence tomography angiography (OCTA) might be of great value for diagnosing or following up patients with these disorders. To date, OCTA has rather been used as an additional tool besides the well-established diagnostic imaging tools, but its complementary diagnostic features become increasingly relevant, to follow disease activity and treatment response and for the understanding of pathomechanisms of various uveitis types. This review summarizes the possible applications of OCTA and its advantages and disadvantages as opposed to dye-based angiographies in uveitic diseases.

Main body: Hitherto gold standards in the diagnostic workup of posterior or intermediate uveitis have been angiography on a dye-based method, which is fluorescein or indocyanine green. It gives information about the status of the blood-retinal barrier and the retinal and choroidal vasculature by visualizing diffuse leakage as a state of inflammation or complications as an ischemia or choroidal neovascularization. As noninvasive methods, fundus autofluorescence depicts the status of metabolic activity of the retinal pigment epithelium and OCT or enhanced depth imaging OCT, respectively, as a depth-resolving imaging method can supply additional information. OCTA as a non-invasive, depth-resolution imaging tool of retinal and choroidal vessels adds detailed qualitative and quantitative information of the status of retinal and choroidal vessels and bridges the gap between the mentioned conventional diagnostic tools used in uveitis. It is important, though, to be aware of its limitations, such as its susceptibility to motion artifacts, limited comparability among different devices, and restricted contribution of information regarding the grade of disease activity.

Conclusion: OCTA as a non-invasive, depth-resolution imaging tool can give qualitative and quantitative information about the status of retinal and choroidal vessels, but also has certain limitations. Employing OCTA as a complementary rather than exclusive tool, it can give important additional information about the macro- and microvasculature under inflammatory circumstances. Thereby, it also contributes to the understanding of the pathophysiology of various uveitis entities.
date: 2019
publisher: Springer
id_scheme: DOI
ppn_swb: 1672118506
own_urn: urn:nbn:de:bsz:16-heidok-265165
language: eng
bibsort: DINGERKUSVOPTICALCOH2019
full_text_status: public
publication: Journal of Ophthalmic Inflammation and Infection
volume: 9
number: 10
place_of_pub: Berlin, Heidelberg
pagerange: 1-28
issn: 1869-5760
citation:   Dingerkus, Vita L. S. ; Munk, Marion R. ; Brinkmann, Max P. ; Freiberg, Florentina J. ; Heussen, Florian M. A. ; Kinzl, Stephan ; Lortz, Sandra ; Orgül, Selim ; Becker, Matthias  (2019) Optical coherence tomography angiography (OCTA) as a new diagnostic tool in uveitis.  Journal of Ophthalmic Inflammation and Infection, 9 (10).  pp. 1-28.  ISSN 1869-5760     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/26516/1/12348_2019_Article_176.pdf