<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Haemoglobinopathies and the Protection Against\r\nSevere Malaria: Probing Cytoadhesion and Mechanics\r\nof Plasmodium falciparum Infected Erythrocytes"^^ . "Haemoglobinopathies and the Protection Against Severe Malaria: Probing Cytoadhesion and\r\nMechanics of Plasmodium falciparum Infected Erythrocytes\r\nAim of this thesis was the probing of the cytoadhesion and the mechanical properties of\r\nPlasmodium falciparum infected human wildtype and haemoglobinopathic erythrocytes, to shed\r\nlight on the protection mechanism against severe malaria associated with haemoglobin\r\npolymorphisms.\r\nIn Chapter 3, the cytoadhesion of infected wildtype and haemoglobinopathic erythrocytes was\r\nprobed using solid-supported lipid bilayers functionalized with CD36 or ICAM-1, acting as in vitro\r\nendothelial cell membrane models. Under static conditions, the binding strength was quantified\r\nin terms of the critical pressure of detachment based on cell detachment by laser induced pressure\r\nwaves. Additionally, the number of binding events and the critical shear stress of detachment\r\nwere determined based on classical parallel plate flow experiments at physiological relevant\r\nshear stresses. Furthermore, the shear stress dependent changes in tight adhesion area were\r\ninvestigated based on label-free reflection interference contrast microscopy.\r\nIn Chapter 4, the parasite induced changes to the erythrocyte mechanics were probed at different\r\nparasite stages using label and contact-free flicker spectroscopy, yielding the membrane bending\r\nmodulus, the membrane tension, the harmonic membrane confinement by the cytoskeleton and\r\nthe apparent cytosolic viscosity.\r\nMoreover, a comprehensive image of the intraerythrocytic parasite metabolism was generated\r\nusing quantitative scanning X-ray fluorescence microscopy."^^ . "2019" . . . . . . . "Benjamin"^^ . "Fröhlich"^^ . "Benjamin Fröhlich"^^ . . . . . . "Haemoglobinopathies and the Protection Against\r\nSevere Malaria: Probing Cytoadhesion and Mechanics\r\nof Plasmodium falciparum Infected Erythrocytes (PDF)"^^ . . . "Dissertation_Froehlich.pdf"^^ . . . "Haemoglobinopathies and the Protection Against\r\nSevere Malaria: Probing Cytoadhesion and Mechanics\r\nof Plasmodium falciparum Infected Erythrocytes (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #26533 \n\nHaemoglobinopathies and the Protection Against \nSevere Malaria: Probing Cytoadhesion and Mechanics \nof Plasmodium falciparum Infected Erythrocytes\n\n" . "text/html" . . . "530 Physik"@de . "530 Physics"@en . .