title: Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project
creator: Bassetti, Matteo
creator: Giacobbe, Daniele R.
creator: Vena, Antonio
creator: Trucchi, Cecilia
creator: Ansaldi, Filippo
creator: Antonelli, Massimo
creator: Adamkova, Vaclava
creator: Alicino, Cristiano
creator: Almyroudi, Maria-Panagiota
creator: Atchade, Enora
creator: Azzini, Anna M.
creator: Carannante, Novella
creator: Carnelutti, Alessia
creator: Corcione, Silvia
creator: Cortegiani, Andrea
creator: Dimopoulos, George
creator: Dubler, Simon
creator: García-Garmendia, José L.
creator: Girardis, Massimo
creator: Cornely, Oliver A.
creator: Ianniruberto, Stefano
creator: Kullberg, Bart Jan
creator: Lagrou, Katrien
creator: Le Bihan, Clement
creator: Luzzati, Roberto
creator: Malbrain, Manu L. N. G.
creator: Merelli, Maria
creator: Marques, Ana J.
creator: Martin-Loeches, Ignacio
creator: Mesini, Alessio
creator: Paiva, José-Artur
creator: Peghin, Maddalena
creator: Raineri, Santi Maurizio
creator: Rautemaa-Richardson, Riina
creator: Schouten, Jeroen
creator: Brugnaro, Pierluigi
creator: Spapen, Herbert
creator: Tasioudis, Polychronis
creator: Timsit, Jean-François
creator: Tisa, Valentino
creator: Tumbarello, Mario
creator: van den Berg, Charlotte H. S. B.
creator: Veber, Benoit
creator: Venditti, Mario
creator: Voiriot, Guillaume
creator: Wauters, Joost
creator: Montravers, Philippe
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe.    Methods: A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU).    Results: During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02–1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31–8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04–1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24–3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis.    Conclusions: The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.
publisher: BioMed Central ; Springer
date: 2019
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/26598/1/13054_2019_Article_2497.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-265981
identifier:   Bassetti, Matteo ; Giacobbe, Daniele R. ; Vena, Antonio ; Trucchi, Cecilia ; Ansaldi, Filippo ; Antonelli, Massimo ; Adamkova, Vaclava ; Alicino, Cristiano ; Almyroudi, Maria-Panagiota ; Atchade, Enora ; Azzini, Anna M. ; Carannante, Novella ; Carnelutti, Alessia ; Corcione, Silvia ; Cortegiani, Andrea ; Dimopoulos, George ; Dubler, Simon ; García-Garmendia, José L. ; Girardis, Massimo ; Cornely, Oliver A. ; Ianniruberto, Stefano ; Kullberg, Bart Jan ; Lagrou, Katrien ; Le Bihan, Clement ; Luzzati, Roberto ; Malbrain, Manu L. N. G. ; Merelli, Maria ; Marques, Ana J. ; Martin-Loeches, Ignacio ; Mesini, Alessio ; Paiva, José-Artur ; Peghin, Maddalena ; Raineri, Santi Maurizio ; Rautemaa-Richardson, Riina ; Schouten, Jeroen ; Brugnaro, Pierluigi ; Spapen, Herbert ; Tasioudis, Polychronis ; Timsit, Jean-François ; Tisa, Valentino ; Tumbarello, Mario ; van den Berg, Charlotte H. S. B. ; Veber, Benoit ; Venditti, Mario ; Voiriot, Guillaume ; Wauters, Joost ; Montravers, Philippe  (2019) Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project.  Critical Care, 23 (219).  pp. 1-7.  ISSN 1466-609X     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/26598/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng