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primary topic: Influence of patient and tumor characteristics on therapy persistence with letrozole in postmenopausal women with advanced breast cancer: results of the prospective observational EvAluate-TM study

Influence of patient and tumor characteristics on therapy persistence with letrozole in postmenopausal women with advanced breast cancer: results of the prospective observational EvAluate-TM study
type: AcademicArticle
type: Article
abstract: Background: Treatment of postmenopausal, hormone receptor-positive metastatic breast cancer (MBC) patients varies despite clear therapy guidelines, favoring endocrine treatment (ET). Aim of this study was to analyze persistence of palliative aromatase inhibitor (AI) monotherapy in MBC patients. Methods: EvAluate-TM is a prospective, multicenter, noninterventional study to evaluate treatment with letrozole in postmenopausal women with hormone receptor–positive breast cancer. To assess therapy persistence, defined as the time from therapy start to the end of the therapy (TTEOT), two pre-specified study visits took place after 6 and 12 months. Competing risk survival analyses were performed to identify patient and tumor characteristics that predict TTEOT. Results: Out of 200 patients, 66 patients terminated treatment prematurely, 26 (13%) of them due to causes other than disease progression. Persistence rate for reasons other than progression at 12 months was 77.7%. Persistence was lower in patients who reported any adverse event (AE) in the first 30 days of ET (89.5% with no AE and 56% with AE). Furthermore, patients had a lower persistence if they reported compliance problems in the past before letrozole treatment. Conclusions: Despite suffering from a life-threatening disease, AEs of an AI will result in a relevant number of treatment terminations that are not related to progression. Some subgroups of patients have very low persistence rates. Especially with regard to novel endocrine combination therapies, these data imply that some groups of patients will need special attention to guide them through the therapy process. Trial registration Clinical Trials Number: CFEM345DDE19
date: 2019
volume: 16
issue: 611
is part of: BMC cancer
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: https://archiv.ub.uni-heidelberg.de/volltextserver/id/document/216747
has document: https://archiv.ub.uni-heidelberg.de/volltextserver/id/document/216758
subject: 610 Medizin

https://archiv.ub.uni-heidelberg.de/volltextserver/id/document/216747
type: Document
label: Influence of patient and tumor characteristics on therapy persistence with letrozole in postmenopausal women with advanced breast cancer: results of the prospective observational EvAluate-TM study (PDF)
has file: 12885_2019_Article_5806.pdf
has part: 12885_2019_Article_5806.pdf

BioMed Central ; Springer
type: Organization

BMC cancer
type: Collection
issn: 14712407

Nadia Harbeck
type: Person
given name: Nadia
family name: Harbeck

Christoph Mundhenke
type: Person
given name: Christoph
family name: Mundhenke

Peter A. Fasching
type: Person
given name: Peter A.
family name: Fasching

Christopher Wolf
type: Person
given name: Christopher
family name: Wolf

Thomas Noesselt
type: Person
given name: Thomas
family name: Noesselt

Andreas Kohls
type: Person
given name: Andreas
family name: Kohls

Andre Hohn
type: Person
given name: Andre
family name: Hohn

Thomas Praetz
type: Person
given name: Thomas
family name: Praetz

Tanja Fehm
type: Person
given name: Tanja
family name: Fehm

Jörg-Uwe Deuker
type: Person
given name: Jörg-Uwe
family name: Deuker

Georg-Peter Breitbach
type: Person
given name: Georg-Peter
family name: Breitbach

Katja Schmidt
type: Person
given name: Katja
family name: Schmidt

Jan Willem Siebers
type: Person
given name: Jan Willem
family name: Siebers

Diethelm Wallwiener
type: Person
given name: Diethelm
family name: Wallwiener

Manuel Feisst
type: Person
given name: Manuel
family name: Feisst

Thomas Kuhn
type: Person
given name: Thomas
family name: Kuhn

Gerold Baake
type: Person
given name: Gerold
family name: Baake

Volker Heyl
type: Person
given name: Volker
family name: Heyl

Hans-Walter Vollert
type: Person
given name: Hans-Walter
family name: Vollert

Hans-Christian Kolberg
type: Person
given name: Hans-Christian
family name: Kolberg

Sara Y. Brucker
type: Person
given name: Sara Y.
family name: Brucker

Christian M. Bayer
type: Person
given name: Christian M.
family name: Bayer

Barbara Richter
type: Person
given name: Barbara
family name: Richter

Thomas Krauss
type: Person
given name: Thomas
family name: Krauss

Matthias W. Beckmann
type: Person
given name: Matthias W.
family name: Beckmann

Markus Wallwiener
type: Person
given name: Markus
family name: Wallwiener

Milos Popovic
type: Person
given name: Milos
family name: Popovic

Johann de Waal
type: Person
given name: Johann
family name: de Waal

Alexander Hein
type: Person
given name: Alexander
family name: Hein

Sherko Kümmel
type: Person
given name: Sherko
family name: Kümmel

Erik Belleville
type: Person
given name: Erik
family name: Belleville

Christoph Thomssen
type: Person
given name: Christoph
family name: Thomssen

Grischa Wachsmann
type: Person
given name: Grischa
family name: Wachsmann

Cosima Brucker
type: Person
given name: Cosima
family name: Brucker

Mathias Warm
type: Person
given name: Mathias
family name: Warm

Daniela Rezek
type: Person
given name: Daniela
family name: Rezek

Rachel Wuerstlein
type: Person
given name: Rachel
family name: Wuerstlein

Peyman Hadji
type: Person
given name: Peyman
family name: Hadji

Robert Landthaler
type: Person
given name: Robert
family name: Landthaler

Andreas Hartkopf
type: Person
given name: Andreas
family name: Hartkopf

Peter Dall
type: Person
given name: Peter
family name: Dall

Bernd Baier
type: Person
given name: Bernd
family name: Baier

Mahdi Rezai
type: Person
given name: Mahdi
family name: Rezai

Stephan Henschen
type: Person
given name: Stephan
family name: Henschen

Martin Guggenberger
type: Person
given name: Martin
family name: Guggenberger

Gunnar Fischer
type: Person
given name: Gunnar
family name: Fischer

Wolfgang Janni
type: Person
given name: Wolfgang
family name: Janni

Hans Tesch
type: Person
given name: Hans
family name: Tesch

Thorsten Kühn
type: Person
given name: Thorsten
family name: Kühn

Naiba Nabieva
type: Person
given name: Naiba
family name: Nabieva

Claudia Rauh
type: Person
given name: Claudia
family name: Rauh

https://archiv.ub.uni-heidelberg.de/volltextserver/id/document/216758
type: Document
label: Influence of patient and tumor characteristics on therapy persistence with letrozole in postmenopausal women with advanced breast cancer: results of the prospective observational EvAluate-TM study (Other)
is version of: https://archiv.ub.uni-heidelberg.de/volltextserver/id/document/216747
is volatile version of: https://archiv.ub.uni-heidelberg.de/volltextserver/id/document/216747
is index codes version of: https://archiv.ub.uni-heidelberg.de/volltextserver/id/document/216747
has file: indexcodes.txt
has part: indexcodes.txt

https://archiv.ub.uni-heidelberg.de/volltextserver/26657/
title: HTML Summary of #26657 Influence of patient and tumor characteristics on therapy persistence with letrozole in postmenopausal women with advanced breast cancer: results of the prospective observational EvAluate-TM study
format: text/html
primary topic: Influence of patient and tumor characteristics on therapy persistence with letrozole in postmenopausal women with advanced breast cancer: results of the prospective observational EvAluate-TM study

610 Medizin
type: Concept
preferred label: 610 Medical sciences Medicine @en