<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Influence of patient and tumor characteristics on therapy persistence with letrozole in postmenopausal women with advanced breast cancer: results of the prospective observational EvAluate-TM study"^^ . "Background: Treatment of postmenopausal, hormone receptor-positive metastatic breast cancer (MBC) patients varies despite clear therapy guidelines, favoring endocrine treatment (ET). Aim of this study was to analyze persistence of palliative aromatase inhibitor (AI) monotherapy in MBC patients.\r\n\r\nMethods: EvAluate-TM is a prospective, multicenter, noninterventional study to evaluate treatment with letrozole in postmenopausal women with hormone receptor–positive breast cancer. To assess therapy persistence, defined as the time from therapy start to the end of the therapy (TTEOT), two pre-specified study visits took place after 6 and 12 months. Competing risk survival analyses were performed to identify patient and tumor characteristics that predict TTEOT.\r\n\r\nResults: Out of 200 patients, 66 patients terminated treatment prematurely, 26 (13%) of them due to causes other than disease progression. Persistence rate for reasons other than progression at 12 months was 77.7%. Persistence was lower in patients who reported any adverse event (AE) in the first 30 days of ET (89.5% with no AE and 56% with AE). Furthermore, patients had a lower persistence if they reported compliance problems in the past before letrozole treatment. \r\n\r\nConclusions: Despite suffering from a life-threatening disease, AEs of an AI will result in a relevant number of treatment terminations that are not related to progression. Some subgroups of patients have very low persistence rates. Especially with regard to novel endocrine combination therapies, these data imply that some groups of patients will need special attention to guide them through the therapy process.\r\n\r\nTrial registration Clinical Trials Number: CFEM345DDE19"^^ . "2019" . . "16" . "611" . . "BioMed Central ; Springer"^^ . . . "BMC cancer"^^ . . . "14712407" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Nadia"^^ . "Harbeck"^^ . "Nadia Harbeck"^^ . . "Christoph"^^ . "Mundhenke"^^ . "Christoph Mundhenke"^^ . . "Peter A."^^ . "Fasching"^^ . "Peter A. Fasching"^^ . . "Christopher"^^ . "Wolf"^^ . "Christopher Wolf"^^ . . "Thomas"^^ . "Noesselt"^^ . "Thomas Noesselt"^^ . . "Andreas"^^ . "Kohls"^^ . "Andreas Kohls"^^ . . "Andre"^^ . "Hohn"^^ . "Andre Hohn"^^ . . "Thomas"^^ . "Praetz"^^ . "Thomas Praetz"^^ . . "Tanja"^^ . "Fehm"^^ . "Tanja Fehm"^^ . . "Jörg-Uwe"^^ . "Deuker"^^ . "Jörg-Uwe Deuker"^^ . . "Georg-Peter"^^ . "Breitbach"^^ . "Georg-Peter Breitbach"^^ . . "Katja"^^ . "Schmidt"^^ . "Katja Schmidt"^^ . . "Jan Willem"^^ . "Siebers"^^ . "Jan Willem Siebers"^^ . . "Diethelm"^^ . "Wallwiener"^^ . "Diethelm Wallwiener"^^ . . "Manuel"^^ . "Feisst"^^ . "Manuel Feisst"^^ . . "Thomas"^^ . "Kuhn"^^ . "Thomas Kuhn"^^ . . "Gerold"^^ . "Baake"^^ . "Gerold Baake"^^ . . "Volker"^^ . "Heyl"^^ . "Volker Heyl"^^ . . "Hans-Walter"^^ . "Vollert"^^ . "Hans-Walter Vollert"^^ . . "Hans-Christian"^^ . "Kolberg"^^ . "Hans-Christian Kolberg"^^ . . "Sara Y."^^ . "Brucker"^^ . "Sara Y. Brucker"^^ . . "Christian M."^^ . "Bayer"^^ . "Christian M. Bayer"^^ . . "Barbara"^^ . "Richter"^^ . "Barbara Richter"^^ . . "Thomas"^^ . "Krauss"^^ . "Thomas Krauss"^^ . . "Matthias W."^^ . "Beckmann"^^ . "Matthias W. Beckmann"^^ . . "Markus"^^ . "Wallwiener"^^ . "Markus Wallwiener"^^ . . "Milos"^^ . "Popovic"^^ . "Milos Popovic"^^ . . "Johann"^^ . "de Waal"^^ . "Johann de Waal"^^ . . "Alexander"^^ . "Hein"^^ . "Alexander Hein"^^ . . "Sherko"^^ . "Kümmel"^^ . "Sherko Kümmel"^^ . . "Erik"^^ . "Belleville"^^ . "Erik Belleville"^^ . . "Christoph"^^ . "Thomssen"^^ . "Christoph Thomssen"^^ . . "Grischa"^^ . "Wachsmann"^^ . "Grischa Wachsmann"^^ . . "Cosima"^^ . "Brucker"^^ . "Cosima Brucker"^^ . . "Mathias"^^ . "Warm"^^ . "Mathias Warm"^^ . . "Daniela"^^ . "Rezek"^^ . "Daniela Rezek"^^ . . "Rachel"^^ . "Wuerstlein"^^ . "Rachel Wuerstlein"^^ . . "Peyman"^^ . "Hadji"^^ . "Peyman Hadji"^^ . . "Robert"^^ . "Landthaler"^^ . "Robert Landthaler"^^ . . "Andreas"^^ . "Hartkopf"^^ . "Andreas Hartkopf"^^ . . "Peter"^^ . "Dall"^^ . "Peter Dall"^^ . . "Bernd"^^ . "Baier"^^ . "Bernd Baier"^^ . . "Mahdi"^^ . "Rezai"^^ . "Mahdi Rezai"^^ . . "Stephan"^^ . "Henschen"^^ . "Stephan Henschen"^^ . . "Martin"^^ . "Guggenberger"^^ . "Martin Guggenberger"^^ . . "Gunnar"^^ . "Fischer"^^ . "Gunnar Fischer"^^ . . "Wolfgang"^^ . "Janni"^^ . "Wolfgang Janni"^^ . . "Hans"^^ . "Tesch"^^ . "Hans Tesch"^^ . . "Thorsten"^^ . "Kühn"^^ . "Thorsten Kühn"^^ . . "Naiba"^^ . "Nabieva"^^ . "Naiba Nabieva"^^ . . "Claudia"^^ . "Rauh"^^ . "Claudia Rauh"^^ . . . . . . "Influence of patient and tumor characteristics on therapy persistence with letrozole in postmenopausal women with advanced breast cancer: results of the prospective observational EvAluate-TM study (PDF)"^^ . . . "12885_2019_Article_5806.pdf"^^ . . . "Influence of patient and tumor characteristics on therapy persistence with letrozole in postmenopausal women with advanced breast cancer: results of the prospective observational EvAluate-TM study (Other)"^^ . . . . . . "indexcodes.txt"^^ . . 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