title: Relaxation-Compensated Amide Chemical Exchange Saturation Transfer MRI of the Human Breast
creator: Zimmermann, Ferdinand
subject: ddc-530
subject: 530 Physics
description: Early detection of breast cancer is associated with reduced mortality. As an adjunct to X-ray mammography, magnetic resonance imaging (MRI) is used for clarification of suspicious lesions. Beyond conventionally applied MRI modalities, chemical exchange saturation transfer (CEST) MRI has the potential to provide insights on biochemical tumor environment. Particularly the amide CEST signal originating from proteins has been shown to correlate with parameters of high clinical relevance. However, in the breast, the amide CEST signal is compromised by fat-signal-induced artifacts. Moreover, a profound interpretation requires an isolation of superimposing CEST signals and correction for water relaxation properties.   The aim of this thesis was to account for these factors and to enable relaxation-compensated amide CEST MRI of the human breast. A general theoretical description allowed the correction for fat-signal-induced artifacts by a novel postprocessing algorithm. In addition, established methods for mapping of water relaxation properties were enhanced for a robust performance in the presence of fat. This enabled – for the first time – examinations of breast cancer patients using relaxation-compensated amide CEST MRI. In three patients a twofold increase of the amide CEST contrast was observed compared to healthy volunteers. Hormonal-induced fluctuations in the amide CEST contrast were shown to be negligible.
date: 2019
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/26678/1/dkfz%20-%20Diss%20--%20Zimmermann%2C%20F%20-%202019%20-%20Relaxation-Compensated%20Amide%20CEST%20MRI%20of%20the%20Human%20Breast.pdf
identifier: DOI:10.11588/heidok.00026678
identifier: urn:nbn:de:bsz:16-heidok-266783
identifier:   Zimmermann, Ferdinand  (2019) Relaxation-Compensated Amide Chemical Exchange Saturation Transfer MRI of the Human Breast.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/26678/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng