title: Real-time blood oxygenation tomography with multispectral photoacoustics
creator: Kirchner, Thomas
subject: ddc-530
subject: 530 Physics
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Multispectral photoacoustics is an emerging biomedical imaging modality which combines the penetration depth and resolution of high frequency medical ultrasonography with an optical absorption contrast. This enables tomographic imaging of blood oxygen saturation, a functional biomarker with wide applications. Already, photoacoustic imaging (PAI) is widely applied for small animal imaging in preclinical research. While PAI is a multiscale modality, its translation to clinical research and interventional use remains challenging. The objective of this thesis was to investigate the usefulness of multispectral PAI as a technique for interventional tomographic imaging of blood  oxygenation. This thesis presents open challenges alongside research contributions to address them. These contributions are, (1) The design and implementation of an interventional PAI system, (2) Methods for real-time photoacoustic (PA) image processing and quantification of tissue absorption and blood oxygenation, and finally (3) the application of multispectral PAI to translational neurosurgical research – performing the first high spatiotemporal resolution tomography of spreading depolarization, and at the same time the first interventional PAI on any gyrencephalic (folded) brain. Such interventional imaging in neurology is one of many promising fields of application for PAI.
date: 2019
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/26696/1/PhD_Thesis_Thomas_Kirchner.1.0.pdf
identifier: DOI:10.11588/heidok.00026696
identifier: urn:nbn:de:bsz:16-heidok-266965
identifier:   Kirchner, Thomas  (2019) Real-time blood oxygenation tomography with multispectral photoacoustics.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/26696/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng