<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Investigating efficient apoptotic corps removal by microglia in the developing brain"^^ . "Abstract:\r\nEvery day millions of cells die in the human body, because of injury, infection, or to maintain\r\nhomeostasis. The most common way for cells to die is through a process of controlled cell\r\ndeath, apoptosis, through which the body eliminates superfluous, or potentially damaged\r\ncells. However, ultimately this material needs to be removed, through phagocytosis, to avoid\r\ninflammation and secondary necrosis. Professional phagocytes deal with this by engulfing and\r\ndigesting a large number of apoptotic cells. The throughput of this process is estimated to be\r\nseveral times the phagocytes own biomass in a 24 hour period. Here, I investigate the process\r\nby which engulfed apoptotic cell material is dealt with. To this end I have developed a\r\ncorrelative light and electron microscopy workflow that allows us to target a specific cell\r\ninside the brain of a zebrafish larvae. I have also made use of state of the art single plane\r\nillumination microscopy for tracking of the dynamic events involved in this process. By\r\nstudying microglia in the optic tectum of zebrafish during a developmental stage\r\ncharacterized by high neuronal apoptosis I have discovered a role for the sugar‐phosphate\r\ntransporter Slc37a2 in shrinking phagosomes as well as a propensity for phagosomes to\r\nundergo fusion resulting in apoptotic corpses being trafficked towards a single compartment\r\ninside the cell. The broader relevance of these findings is expanded on through the\r\ndevelopment of a cell culture model to study this compartment which allowed us to\r\ncharacterize it in further detail. This compartment has a unique ultrastructure and a molecular\r\nsignature indicating it is involved in lipid metabolism and possibly phagosome resolution."^^ . "2019" . . . . . . . "Jørgen"^^ . "Benjaminsen"^^ . "Jørgen Benjaminsen"^^ . . . . . . "Investigating efficient apoptotic corps removal by microglia in the developing brain (PDF)"^^ . . . "Dissertation_Benjaminsen_16_12_18.pdf"^^ . . . "Investigating efficient apoptotic corps removal by microglia in the developing brain (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #26698 \n\nInvestigating efficient apoptotic corps removal by microglia in the developing brain\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .