title: Adaptive propensity score procedure improves matching in prospective observational trials
creator: Weber, Dorothea
creator: Uhlmann, Lorenz
creator: Schönenberger, Silvia
creator: Kieser, Meinhard
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: Randomized controlled trials are the gold-standard for clinical trials. However, randomization is not always feasible. In this article we propose a prospective and adaptive matched case-control trial design assuming that a control group already exists.    Methods: We propose and discuss an interim analysis step to estimate the matching rate using a resampling step followed by a sample size recalculation. The sample size recalculation is based on the observed mean resampling matching rate. We applied our approach in a simulation study and to a real data set to evaluate the characteristics of the proposed design and to compare the results to a naive approach.    Results: The proposed design achieves at least 10% higher matching rate than the naive approach at final analysis, thus providing a better estimation of the true matching rate. A good choice for the interim analysis seems to be a fraction of around 1/2 to 2/3 of the control patients.    Conclusion: The proposed resampling step in a prospective matched case-control trial design leads to an improved estimate of the final matching rate and, thus, to a gain in power of the approach due to sensible sample size recalculation.
publisher: BioMed Central ; Springer
date: 2019
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/26829/1/12874_2019_Article_763.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-268295
identifier:   Weber, Dorothea ; Uhlmann, Lorenz ; Schönenberger, Silvia ; Kieser, Meinhard  (2019) Adaptive propensity score procedure improves matching in prospective observational trials.  BMC Medical Research Methodology, 19 (150).  pp. 1-11.  ISSN 1471-2288     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/26829/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng