title: A prognostic CpG score derived from epigenome-wide profiling of tumor tissue was independently associated with colorectal cancer survival
creator: Jia, Min
creator: Zhang, Yan
creator: Jansen, Lina
creator: Walter, Viola
creator: Edelmann, Dominic
creator: Gündert, Melanie
creator: Tagscherer, Katrin E.
creator: Roth, Wilfried
creator: Bewerunge-Hudler, Melanie
creator: Herpel, Esther
creator: Kloor, Matthias
creator: Ulrich, Alexis
creator: Burwinkel, Barbara
creator: Bläker, Hendrik
creator: Chang-Claude, Jenny
creator: Brenner, Hermann
creator: Hoffmeister, Michael
subject: 610
subject: 610 Medical sciences Medicine
description: Background: Results of previous studies on the association of the CpG island methylator phenotype (CIMP) with colorectal cancer (CRC) prognosis were inconsistent and mostly based on different CIMP definitions. The current study aimed to comprehensively investigate the associations between DNA methylation on genes previously used to define CIMP status with CRC survival.    Results: Patients with CRC followed up for a median of 5.2 years were divided into a study cohort (n = 568) and a validation cohort (n = 308). DNA methylation was measured in tumor tissue using the Illumina Infinium HumanMethylation450 BeadChip and restricted to 43 genes used to define CIMP status in previous studies. Cox proportional hazard regression models were used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) of survival after CRC, including adjustment for tumor stage, microsatellite instability, and BRAF mutation status. In the study cohort, ten CpG sites were identified to be associated with CRC survival. Seven of these ten CpG sites were also associated with CRC survival in the validation cohort and were used to construct a prognostic score. CRC patients with a prognostic score of the lowest methylation level showed poorer disease-specific survival compared with patients with the highest methylation level in both the study cohort and the validation cohort (HR = 3.11 and 95% CI = 1.97–4.91, and HR = 3.06 and 95% CI = 1.71–5.45, respectively).    Conclusions: A CpG panel consisting of seven CpG sites was found to be strongly associated with CRC survival, independent from important clinical factors and mutations associated with CIMP. Further studies are required to confirm these findings.
publisher: BioMed Central ; Springer
date: 2019
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/26894/1/13148_2019_Article_703.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-268946
identifier:   Jia, Min ; Zhang, Yan ; Jansen, Lina ; Walter, Viola ; Edelmann, Dominic ; Gündert, Melanie ; Tagscherer, Katrin E. ; Roth, Wilfried ; Bewerunge-Hudler, Melanie ; Herpel, Esther ; Kloor, Matthias ; Ulrich, Alexis ; Burwinkel, Barbara ; Bläker, Hendrik ; Chang-Claude, Jenny ; Brenner, Hermann ; Hoffmeister, Michael  (2019) A prognostic CpG score derived from epigenome-wide profiling of tumor tissue was independently associated with colorectal cancer survival.  Clinical Epigenetics, 11 (109).  pp. 1-11.  ISSN 1868-7083     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/26894/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng