eprintid: 26940
rev_number: 15
eprint_status: archive
userid: 1589
dir: disk0/00/02/69/40
datestamp: 2019-08-20 14:09:53
lastmod: 2019-10-02 10:19:52
status_changed: 2019-08-20 14:09:53
type: article
metadata_visibility: show
creators_name: Kremer, Jamila
creators_name: Preisner, Fabian
creators_name: Dib, Bashar
creators_name: Tochtermann, Ursula
creators_name: Ruhparwar, Arjang
creators_name: Karck, Matthias
creators_name: Farag, Mina
title: Aortic arch replacement with frozen elephant trunk technique – a single-center study
subjects: ddc-610
divisions: i-911200
divisions: i-911400
keywords: Aortic disease, Frozen elephant trunk, Follow-up downstream aorta
abstract: Background: The frozen elephant trunk (FET) technique was developed to facilitate the two-stage surgery of extensive pathologies of the thoracic aorta and is now routinely applied in acute and chronic aortic syndromes.   

Methods: From 11/2006 to 07/2017, 68 patients underwent aortic arch repair using the FET technique. Patients received either the Jotec E-vita Open graft (n = 57) or the Vascutek Thoraflex hybrid prosthesis (n = 11). Both, group 1 (acute aortic dissection type A and B; symptomatic penetrating aortic ulcer) and group 2 (aortic aneurysm; chronic aortic dissection) included 34 patients each.

Results: Early mortality was 13.2% (14.7% in group 1 vs. 11.7% in group 2, p = 0.720). Neurological complications occurred in 12 patients (17.6%) (stroke: 8.8 vs. 11.7%; p = 0.797 and spinal cord injury: 8.8 vs. 5.9%; p = 0.642 in groups 1 vs. 2 respectively). Cardiopulmonary bypass time and cross clamp time were significantly longer in group 1 (252.2 ± 73.5 and 148.3 ± 34 min vs. 189.2 ± 47.8 and 116.3 ± 34.5 min; p <  0.001). The overall 1-, 3- and 7-year-survival was 80.9, 80.9 and 74.2% with no significant differences between groups 1 and 2. Expansion of true lumen after FET implantation was significant at all levels in both groups for patients with aortic dissection. One-, 3-, and 7-year-freedom from secondary (re-)intervention for patients for aortic dissection was 96.9, 90.2 and 82.7% with no significant differences between groups 1 and 2; p = 0.575.

Conclusion: The FET technique can be applied in acute aortic syndromes with similar risks regarding adverse events or mortality when compared to chronic degenerative aortic disease. Postoperative increase in true lumen diameter mirrors decrease of false lumen diameter, goes along with favorable midterm outcome and prolongs freedom from secondary interventions in acute aortic dissection.
date: 2019
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1678053589
own_urn: urn:nbn:de:bsz:16-heidok-269409
language: eng
bibsort: KREMERJAMIAORTICARCH2019
full_text_status: public
publication: Journal of Cardiothoracic Surgery
volume: 14
number: 147
place_of_pub: London
pagerange: 1-10
issn: 1749-8090
citation:   Kremer, Jamila ; Preisner, Fabian ; Dib, Bashar ; Tochtermann, Ursula ; Ruhparwar, Arjang ; Karck, Matthias ; Farag, Mina  (2019) Aortic arch replacement with frozen elephant trunk technique – a single-center study.  Journal of Cardiothoracic Surgery, 14 (147).  pp. 1-10.  ISSN 1749-8090     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/26940/1/13019_2019_Article_969.pdf