TY  - JOUR
A1  - Domschke, Christoph
A1  - Schneeweiss, Andreas
A1  - Stefanovic, Stefan
A1  - Wallwiener, Markus
A1  - Heil, Joerg
A1  - Rom, Joachim
A1  - Sohn, Christof
A1  - Beckhove, Philipp
A1  - Schuetz, Florian
N2  - More recently, immunotherapy has emerged as a novel potentially effective therapeutic option also for solid malignancies such as breast cancer (BC). Relevant approaches, however, are determined by the 2 main elements of cancer immunoediting - the elimination of nascent transformed cells by immunosurveillance on the one hand and tumor immune escape on the other hand. Correspondingly, we here review the role of the various cellular immune players within the host-protective system and dissect the mechanisms of immune evasion leading to tumor progression. If the immune balance of disseminated BC cell dormancy (equilibrium phase) is lost, distant metastatic relapse may occur. The relevant cellular antitumor responses and translational immunotherapeutic options will also be discussed in terms of clinical benefit and future directions in BC management.
UR  - https://doi.org/10.1159/000446061
Y1  - 2016///
IS  - 2
SN  - 1661-3791
N1  - Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich.

This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 11
EP  - 107
PB  - S. Karger
TI  - Cellular Immune Responses and Immune Escape Mechanisms in Breast Cancer: Determinants of Immunotherapy
SP  - 102
JF  - Breast Care
AV  - public
ID  - heidok27046
ER  -