eprintid: 27046
rev_number: 13
eprint_status: archive
userid: 1249
dir: disk0/00/02/70/46
datestamp: 2019-09-04 09:24:29
lastmod: 2024-04-27 21:23:39
status_changed: 2019-09-04 09:24:29
type: article
metadata_visibility: show
creators_name: Domschke, Christoph
creators_name: Schneeweiss, Andreas
creators_name: Stefanovic, Stefan
creators_name: Wallwiener, Markus
creators_name: Heil, Joerg
creators_name: Rom, Joachim
creators_name: Sohn, Christof
creators_name: Beckhove, Philipp
creators_name: Schuetz, Florian
title: Cellular Immune Responses and Immune Escape Mechanisms in Breast Cancer: Determinants of Immunotherapy
subjects: 610
divisions: 910400
note: Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich.

This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
abstract: More recently, immunotherapy has emerged as a novel potentially effective therapeutic option also for solid malignancies such as breast cancer (BC). Relevant approaches, however, are determined by the 2 main elements of cancer immunoediting - the elimination of nascent transformed cells by immunosurveillance on the one hand and tumor immune escape on the other hand. Correspondingly, we here review the role of the various cellular immune players within the host-protective system and dissect the mechanisms of immune evasion leading to tumor progression. If the immune balance of disseminated BC cell dormancy (equilibrium phase) is lost, distant metastatic relapse may occur. The relevant cellular antitumor responses and translational immunotherapeutic options will also be discussed in terms of clinical benefit and future directions in BC management.
date: 2016
publisher: S. Karger
id_scheme: DOI
official_url: https://doi.org/10.1159/000446061
ppn_swb: 1678042439
own_urn: urn:nbn:de:bsz:16-heidok-270468
language: eng
bibsort: DOMSCHKECHCELLULARIM2016
full_text_status: public
publication: Breast Care
volume: 11
number: 2
pagerange: 102-107
issn: 1661-3791
citation:   Domschke, Christoph ; Schneeweiss, Andreas ; Stefanovic, Stefan ; Wallwiener, Markus ; Heil, Joerg ; Rom, Joachim ; Sohn, Christof ; Beckhove, Philipp ; Schuetz, Florian  (2016) Cellular Immune Responses and Immune Escape Mechanisms in Breast Cancer: Determinants of Immunotherapy.  Breast Care, 11 (2).  pp. 102-107.  ISSN 1661-3791     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/27046/1/446061.pdf