<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Ca2+ signalling and its consequences in the mouse\r\nspinal cord dorsal horn under chronic pain"^^ . "Chronic pain represents one major health problem of today’s global society. Some\r\ntreatments fail and still many aspects of chronic pain development and maintenance\r\nare unknown. Here, we present new insights into the Ca2+ signalling behaviour of acute\r\nslices of murine spinal cord dorsal horn astrocytes and parvalbumin(PV)-positive\r\nneurons. To our knowledge we showed here for the first time that stimulation of\r\npreferred fibre classes from the dorsal root evokes Ca2+ signalling in the cytosol and\r\nnucleus of astrocytes and the cytosol of PV-neurons. In addition, we detected a\r\ndecrease of these evoked Ca2+ signals under neuropathic pain conditions when\r\nstimulated with Aβ- or Aδ-fibre preferred frequencies. We did not observe differences\r\nunder chronic inflammatory pain conditions, neither in astrocytes nor in PV-positive\r\nneurons. Further investigation showed that the Ca2+ signalling dependent immediate\r\nearly gene Npas4 was reduced 3 days after neuropathic pain induction and that\r\noverexpression of NPAS4 in spinal dorsal horn neurons in vivo, leads to a rescue of\r\nmechanical but not thermal hypersensitivity. These findings suggest an important role\r\nof the Ca2+ signalling behaviour of astrocytes in response to Aβ- and Aδ-fibre\r\nstimulation under neuropathic pain under the tested conditions. Especially because of\r\nthe occurrence of Ca2+ signalling in the astrocytic nucleus, we propose a similar gene\r\nregulation function as in neurons, which probably induce plasticity changes in\r\nastrocytes. This might be due to adaption to the neuronal activity required to transmit\r\nsignals from the periphery to the brain, which is possibly disturbed under chronic pain\r\nconditions. Thus, the purpose of astrocytes to support those changes in pain\r\nconditions would also require changes in signalling behaviour. In addition we\r\nhypothesize an important role of NPAS4 regulation in the spinal cord dorsal horn under\r\nneuropathic pain conditions, primarily to control the inhibition of pain stimuli."^^ . "2019" . . . . . . . "Sara"^^ . "Ben Ayed"^^ . "Sara Ben Ayed"^^ . . . . . . "Ca2+ signalling and its consequences in the mouse\r\nspinal cord dorsal horn under chronic pain (PDF)"^^ . . . "PhD_Sara Ben Ayed.pdf"^^ . . . "Ca2+ signalling and its consequences in the mouse\r\nspinal cord dorsal horn under chronic pain (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #27225 \n\nCa2+ signalling and its consequences in the mouse \nspinal cord dorsal horn under chronic pain\n\n" . "text/html" . .