eprintid: 27234
rev_number: 18
eprint_status: archive
userid: 1249
dir: disk0/00/02/72/34
datestamp: 2019-10-11 12:25:31
lastmod: 2020-02-19 07:58:33
status_changed: 2019-10-11 12:25:31
type: article
metadata_visibility: show
creators_name: Häfner, Matthias F.
creators_name: Debus, Jürgen
title: Radiotherapy for Colorectal Cancer: Current Standards and Future Perspectives
subjects: ddc-610
divisions: i-911400
keywords: Radiotherapy , Colorectal cancer , Chemoradiotherapy , Rectal cancer
note: Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich.

This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
abstract: Background: Multimodal treatment approaches are indispensable for patients with advanced-stage colorectal cancer. Radiotherapy has been established as essential part of perioperative concepts and was introduced as an option to face challenges such as local relapse or oligometastases. 

Methods: A literature review was performed to summarize evidence and current standards of radiotherapeutic concepts in the treatment of colorectal cancer. 

Results: For stage II/III rectal cancer, neoadjuvant radiotherapy is superior to adjuvant treatment. Two preoperative regimens have been established and are commonly used with different objectives: short-course radiotherapy (SC-RT) and long-course chemoradiotherapy (LC-CRT). Both reduce the risk of local relapse. Additionally, LC-CRT aims at downsizing the tumor to potentially reduce radicalness of surgery. There is increasing evidence that not all stage II/III rectal cancer patients need neoadjuvant irradiation but also that in some cases surgery might be omitted. Stereotactic body radiotherapy (SBRT) of the liver shows high rates of local control in oligometastatic patients. Intraoperative and particle radiotherapy extend the spectrum of treatment options for locally recurrent patients. 

Conclusion: Radiotherapeutic concepts are crucial for the primary management of locally advanced colorectal cancer and can essentially contribute to treatment approaches in locally recurrent, oligometastatic or palliative patients.
date: 2016
publisher: Karger
id_scheme: DOI
id_number: 10.11588/heidok.00027234
official_url: https://doi.org/10.1159/000446486
ppn_swb: 1678794872
own_urn: urn:nbn:de:bsz:16-heidok-272344
language: eng
bibsort: HAFNERMATTRADIOTHERA2016
full_text_status: public
publication: Visceral Medicine
volume: 32
number: 3
place_of_pub: Basel
pagerange: 172-177
issn: 2297-4725 (Druck-Ausg.), 2297-475X (Online-Ausg.)
citation:   Häfner, Matthias F. ; Debus, Jürgen  (2016) Radiotherapy for Colorectal Cancer: Current Standards and Future Perspectives.  Visceral Medicine, 32 (3).  pp. 172-177.  ISSN 2297-4725 (Druck-Ausg.), 2297-475X (Online-Ausg.)     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/27234/1/446486.pdf