eprintid: 27241
rev_number: 17
eprint_status: archive
userid: 1249
dir: disk0/00/02/72/41
datestamp: 2019-10-21 07:34:53
lastmod: 2020-02-19 07:54:50
status_changed: 2019-10-21 07:34:53
type: article
metadata_visibility: show
creators_name: Safi, Seyer
creators_name: Rauch, Geraldine
creators_name: op den Winkel, Jan
creators_name: Kunz, Josef
creators_name: Schneider, Thomas
creators_name: Bischof, Marc
creators_name: Heussel, Claus Peter
creators_name: Huber, Peter E.
creators_name: Herth, Felix J.F.
creators_name: Dienemann, Hendrik
creators_name: Hoffmann, Hans
title: Sublobar Resection, Radiofrequency Ablation or Radiotherapy in Stage I Non-Small Cell Lung Cancer
subjects: ddc-610
divisions: i-850300
divisions: i-911800
divisions: i-950900
keywords: lung cancer surgery , radiation therapy , ablation
note: Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich.

This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
abstract: BACKGROUND: The best therapy for patients with stage I nonsmall cell lung cancer (NSCLC) who are medically unfit for lobectomy or prefer not to undergo surgery has not yet been demonstrated. 

OBJECTIVES: We analyzed data from our prospective database to evaluate the recurrence and survival rates and assess the extent to which the type of treatment explains outcome differences. 

METHODS: This study included 116 patients with histologically proven clinical stage I NSCLC who were treated with sublobar resection (SLR; n = 42), radiofrequency ablation (RFA; n = 25) or radiotherapy (RT; n = 49) between 2009 and 2013. The primary end point was the time to primary tumor recurrence (PR). Kaplan-Meier curves and Cox regression were used to compare the recurrence patterns and survivals after adjustments for potential confounders. 

RESULTS: The SLR patients were younger and exhibited better performance status. The RT patients had larger tumors. After adjusting for age and tumor size, there were differences between the different treatments in terms of the PR rate, but no differences were observed in overall (OS) or disease-free survival. The hazard ratio for PR comparing SLR versus RT adjusted for age and tumor size was 2.73 (95% confidence interval, CI, 0.72–10.27) and that for SLR versus RFA was 7.57 (95% CI 1.94–29.47). 

CONCLUSIONS: Our study suggests that SLR was associated with a higher primary tumor control rate compared to RFA or RT, although the OSs were not different. These results should be confirmed in prospective trials.
date: 2015
publisher: Karger
id_scheme: DOI
id_number: 10.11588/heidok.00027241
official_url: https://doi.org/10.1159/000381555
ppn_swb: 1680721194
own_urn: urn:nbn:de:bsz:16-heidok-272411
language: eng
bibsort: SAFISEYERSUBLOBARRE2015
full_text_status: public
publication: Respiration
volume: 89
number: 6
place_of_pub: Basel
pagerange: 550-557
issn: 0025-7931 (Print-Ausg.), 1423-0356 (Online-Ausg.)
citation:   Safi, Seyer ; Rauch, Geraldine ; op den Winkel, Jan ; Kunz, Josef ; Schneider, Thomas ; Bischof, Marc ; Heussel, Claus Peter ; Huber, Peter E. ; Herth, Felix J.F. ; Dienemann, Hendrik ; Hoffmann, Hans  (2015) Sublobar Resection, Radiofrequency Ablation or Radiotherapy in Stage I Non-Small Cell Lung Cancer.  Respiration, 89 (6).  pp. 550-557.  ISSN 0025-7931 (Print-Ausg.), 1423-0356 (Online-Ausg.)     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/27241/1/381555.pdf