title: Immunotherapy of Colorectal Cancer
creator: Jäger, Dirk
creator: Halama, Niels
creator: Zörnig, Inka
creator: Klug, Paula
creator: Krauss, Jürgen
creator: Haag, Georg-Martin
subject: ddc-610
subject: 610 Medical sciences Medicine
description: It is known that the immune response, reflected by high T cell infiltrates in primary tumors and metastases, influences the clinical course of colorectal cancer (CRC). Therefore, immunotherapy concepts have been adapted from other tumor entities, which typically rely on the activation of T cells in the tumor microenvironment (e.g. blockade of the immune checkpoint molecules PD-1 and CTLA-4). However, most of the strategies using the approved checkpoint inhibitors and/or combination strategies have more or less failed to produce impressive results in early phase trials in CRC. Therefore, a number of novel targets for checkpoint inhibition are currently in early phase clinical testing (TIM-3, Lag-3, OX40, GITR, 4-1BB, CD40, CD70). A simple activation of infiltrating T cells will not, however, lead to a meaningful anti-tumor response without modulating the environmental factors in CRC. Thus, it is absolutely necessary to improve our understanding of the complex regulation of the tumor microenvironment in CRC to design individual combination treatments leading to effective immune control.
publisher: Karger
date: 2016
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/27245/1/446713.pdf
identifier: DOI:10.11588/heidok.00027245
identifier: https://doi.org/10.1159/000446713
identifier: urn:nbn:de:bsz:16-heidok-272452
identifier:   Jäger, Dirk ; Halama, Niels ; Zörnig, Inka ; Klug, Paula ; Krauss, Jürgen ; Haag, Georg-Martin  (2016) Immunotherapy of Colorectal Cancer.  Oncology Research and Treatment, 39 (6).  pp. 346-350.  ISSN 2296-5270 (Druck-Ausg.), 2296-5262 (Online-Ausg.)     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/27245/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng