title: Motion Management for Carbon Ion Therapy at the Heidelberg Ion-Beam Therapy Center
creator: Härtig, Martin Matthias
subject: ddc-530
subject: 530 Physics
subject: ddc-600
subject: 600 Technology (Applied sciences)
subject: ddc-610
subject: 610 Medical sciences Medicine
description: In 2011, stereotactic body radiotherapy was introduced for the treatment of hepatocellular carcinoma at the Heidelberg Ion-Beam Therapy Center (HIT). Initially, thirteen patients were treated, including the first patient treated using respiratory beam gating. This thesis presents the work flow and data acquisition for the treatment of moving organs. Based on the acquired patient data, simulated and reconstructed 4D dose distributions are now available.    Simulations of 4D dose distributions require precise knowledge of the organ motion and accelerator timing. To improve the prediction, the properties of the HIT synchrotron cycle were investigated, revealing energy-dependent and stochastic aspects and day-to-day beam intensity fluctuations. A simulation was implemented based on a realistic model of the accelerator. The accuracy of calculated irradiation sequences was verified using treatment records. Experimental verification using a patient treatment plan was performed in a moving water phantom, where a total dose deviation of (1.0±7.3)% was determined.    Since 2012, the HIT heavy-ion gantry offers new treatment options. In a treatment planning study, optimal plan geometries for the treatment of esophageal carcinoma were determined. Effects of intrafractional organ motion were accounted for in a quasi-static dose calculation. Results can potentially be used for margin and gating window definition.
date: 2019
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/27269/1/2019-09-09-thesis-mhaertig-Final-PDFen.pdf
identifier: DOI:10.11588/heidok.00027269
identifier: urn:nbn:de:bsz:16-heidok-272697
identifier:   Härtig, Martin Matthias  (2019) Motion Management for Carbon Ion Therapy at the Heidelberg Ion-Beam Therapy Center.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/27269/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng