<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Integrative modeling of Transcription Factor cooperativity and its effects on phenotypic variability"^^ . "The regulation of biological processes relies on a complex nucleotide code embedded in our DNA. Its decoding and interpretation is the main task of Transcription Factors (TFs), which altogether enable the recognition and modulation of gene expression. Whenever factors bind to DNA, a set of additional criteria and conditions need to be satisfied, such as TF concentration, DNA openness, and cooperativity with other binding factors. Such combinations of DNA-bound TFs, as well as their structural and functional cooperativity, allow a more fine-grained control of gene expression due to subtle changes in specificity in both DNA recognition and functional outcomes. This thesis explores the prediction of structural TF cooperativity and its biological consequences. Additionally, examples of functional cooperativity are presented and discussed in the context of neuronal activity and reprogramming. Altogether, this dissertation provides an extensive set of insights to better understand the complex interplay between TFs cooperativity and phenotypes."^^ . "2020" . . . . . . . "Ignacio"^^ . "Ibarra Del Río"^^ . "Ignacio Ibarra Del Río"^^ . . . . . . "Integrative modeling of Transcription Factor cooperativity and its effects on phenotypic variability (PDF)"^^ . . . "ibarra_del_rio_thesis_2020.pdf"^^ . . . "Integrative modeling of Transcription Factor cooperativity and its effects on phenotypic variability (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Integrative modeling of Transcription Factor cooperativity and its effects on phenotypic variability (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Integrative modeling of Transcription Factor cooperativity and its effects on phenotypic variability (Other)"^^ . . . . . . "small.jpg"^^ . . . "Integrative modeling of Transcription Factor cooperativity and its effects on phenotypic variability (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Integrative modeling of Transcription Factor cooperativity and its effects on phenotypic variability (Other)"^^ . . . . . . "preview.jpg"^^ . . "HTML Summary of #27416 \n\nIntegrative modeling of Transcription Factor cooperativity and its effects on phenotypic variability\n\n" . "text/html" . . . "000 Allgemeines, Wissenschaft, Informatik"@de . "000 Generalities, Science"@en . . . "500 Naturwissenschaften und Mathematik"@de . "500 Natural sciences and mathematics"@en . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .