<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Collective synchronization of coupled self-orgnanizing mouse embryonic oscillators"^^ . "Synchronization abounds in nature at different scale and biological context:\r\nfireflies flash in sync, neurons fire together. Synchronization is the ability to coordinate\r\nevents to operate in unison. It requires objects to sense and communicate with each\r\nother. This interaction is called coupling. How synchronization and coupling are achieved\r\nin nature are subject of intense studies.\r\nOne remarkable case of synchronization has been observed during the formation\r\nof the body axis in vertebrates. In vertebrates, the segmented vertebral column is\r\nestablished during somitogenesis at the embryonic stages. Somites form rhythmically,\r\nfor example in mouse with a period of about 2 hours. This process is associated with the\r\noscillatory activity of genes involved in Notch, Wnt and Fgf signalling pathways along the\r\npre somitic mesoderm (PSM) tissue. Interestingly, in vitro randomization assays\r\nincluding tissue dissociation and re-aggregation, PSM cells spontaneously re-synchronize\r\nand self-organize into several miniature emergent PSM structures (ePSM). Thus, a\r\nrandomized ensemble of genetic oscillators with different frequencies and phases\r\nestablish synchrony and form ordered oscillating patterns. Although the requirement for\r\nNotch signalling pathway for synchronization is known, the general rules of coupling\r\nremain elusive.\r\nTo describe synchronization between coupled biological oscillators, Kuramoto in\r\n1979 provided a model based on phase difference coupling. This model assumes that\r\nsynchronization is continuous and driven by the phase difference between weakly\r\ncoupled oscillators. This Kuramoto model is widely used to study synchronization\r\nphenomena, including PSM oscillations . However, theoretical predictions regarding the\r\ncollective phase synchronization have not been tested experimentally yet. We developed\r\na novel experimental strategy to quantitatively challenge the Kuramoto model,\r\nparticularly in regard to its prediction of how the collective phase is determined. While\r\nthe Kuramoto model predicts that the collective phase is equal to phase average of input\r\noscillators, our results suggest that the collective phase is dictated by one phase of input\r\noscillators. Combined with other results, our experimental findings do not match\r\nKuramoto model predictions. I discuss future experimental strategies to test alternative\r\nmodels for PSM synchronization."^^ . "2020" . . . . . . . . "Christine"^^ . "Ho"^^ . "Christine Ho"^^ . . . . . . "Collective synchronization of coupled self-orgnanizing mouse embryonic oscillators (PDF)"^^ . . . "remerciements.pdf"^^ . . . "Collective synchronization of coupled self-orgnanizing mouse embryonic oscillators (PDF)"^^ . . . "Thesis Christine Ho_V8.pdf"^^ . . . "Collective synchronization of coupled self-orgnanizing mouse embryonic oscillators (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #27590 \n\nCollective synchronization of coupled self-orgnanizing mouse embryonic oscillators\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .