eprintid: 29374
rev_number: 16
eprint_status: archive
userid: 3730
dir: disk0/00/02/93/74
datestamp: 2021-02-09 16:52:39
lastmod: 2022-02-12 12:00:01
status_changed: 2021-02-09 16:52:39
type: article
metadata_visibility: show
creators_name: Günther, Frank
creators_name: Blessing, Brigitte
creators_name: Dapunt, Ulrike
creators_name: Mischnik, Alexander
creators_name: Mutters, Nico T.
title: Ability of chlorhexidine, octenidine, polyhexanide and chloroxylenol to inhibit metabolism of biofilm-forming clinical multidrug-resistant organisms
subjects: ddc-610
divisions: i-911460
divisions: i-911700
keywords: Chlorhexidine, octenidine, multidrug resistant gram-negatives, hospital-acquired infection, MRSA, biofilm
note: Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich. *** This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
abstract: Purpose: This in vitro study was designed to determine if standard antiseptics used for skin and environmental surface cleansing can disrupt the metabolic activity (as a measure of viability) of multidrug-resistant gram-negative bacteria, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus isolates within their native biofilms.

Methods: Sixty clinical isolates of multidrug-resistant bacteria were selected for testing in different chlorhexidine gluconate, octenidine, polyhexanide and chloroxylenol concentrations. Metabolic inhibition of biofilm for each clinical isolate was analysed using a biofilm viability assay.

Results: Chlorhexidine gluconate (mean = 83.8% ± 9.8%) and octenidine (mean = 84.5% ± 6.8%) showed the greatest efficacy against biofilms of the tested microorganisms, with the greatest efficacies against MRSA. The antiseptics demonstrated the least efficacy against biofilms of Pseudomonas aeruginosa.

Conclusion: Chlorhexidine gluconate and octenidine showed the greatest level of bacterial metabolic inhibition and were statistically equivalent. Polyhexanide was more effective than chloroxylenol, but both were inferior to chlorhexidine gluconate and octenidine against the tested organisms.
date: 2021
publisher: Sage
id_scheme: DOI
id_number: 10.11588/heidok.00029374
official_url: https://doi.org/10.1177/1757177420963829
ppn_swb: 176375183X
own_urn: urn:nbn:de:bsz:16-heidok-293749
language: eng
bibsort: GUNTHERFRAABILITYOFC2021
full_text_status: public
publication: Journal of Infection Prevention
volume: 22
number: 1
place_of_pub: London
pagerange: 12-18
issn: 1757-1774 (Druck-Ausg.); 1757-1782 (Online-Ausg.)
edition: Zweitveröffentlichung
citation:   Günther, Frank ; Blessing, Brigitte ; Dapunt, Ulrike ; Mischnik, Alexander ; Mutters, Nico T.  (2021) Ability of chlorhexidine, octenidine, polyhexanide and chloroxylenol to inhibit metabolism of biofilm-forming clinical multidrug-resistant organisms.  Journal of Infection Prevention, 22 (1).  pp. 12-18.  ISSN 1757-1774 (Druck-Ausg.); 1757-1782 (Online-Ausg.)     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/29374/1/10.1177_1757177420963829.pdf