TY  - JOUR
Y1  - 2021///
KW  - Copeptin
KW  -  diagnosis
KW  -  right heart failure
KW  -  right heart function
KW  -  right ventricle
UR  - https://doi.org/10.1177/0004563221989364
A1  - Harbrücker, Melissa
A1  - Natale, Michèle
A1  - Kim, Seung-Hyun
A1  - Müller, Julian
A1  - Ansari, Uzair
A1  - Huseynov, Aydin
A1  - Zworowsky, Max von
A1  - Borggrefe, Martin
A1  - Hoffmann, Ursula
A1  - Lang, Siegfried
A1  - Fatar, Marc
A1  - Roth, Thomas
A1  - Kittel, Maximilian
A1  - Bertsch, Thomas
A1  - Akin, Ibrahim
A1  - Behnes, Michael
SN  - 0004-5632 (Druck-Ausg.), 1758-1001 (Online-Ausg.)
TI  - Copeptin reliably reflects longitudinal right ventricular function
PB  - Sage
IS  - 4
JF  - Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
ID  - heidok30223
N2  - Background: Data is limited evaluating novel biomarkers in right ventricular dysfunction. Normal right heart function improves the prognosis of patients with heart failure. Therefore, this study investigates the association between the novel biomarker copeptin and right heart function compared to NT-proBNP.

Methods: Patients undergoing routine echocardiography were enrolled prospectively. Right ventricular function was assessed by tricuspid annular plane systolic excursion (TAPSE) and further right ventricular and atrial parameters. Exclusion criteria were age under 18?years, left ventricular ejection fraction?<?50% and moderate to severe valvular heart disease. Blood samples were taken for biomarker measurements within 72?h of echocardiography.

Results: Ninety-one patients were included. Median values of copeptin increased significantly according to decreasing values of TAPSE (P?=?0.001; right heart function grade I: tricuspid annular plane systolic excursion; TAPSE?>?24?mm: 5.20?pmol/L; grade II: TAPSE 18?24?mm: 8.10?pmol/L; grade III: TAPSE?<?18?mm: 26.50?pmol/L). Copeptin concentrations were able to discriminate patients with decreased right heart function defined as TAPSE?<?18?mm (area under the curves [AUC]: copeptin: 0.793; P?=?0.001; NT-proBNP: 0.805; P?=?0.0001). Within a multivariable linear regression model, copeptin was independently associated with TAPSE (copeptin: T: ?4.43; P?=?0.0001; NT-proBNP: T: ?1.21; P?=?0.23). Finally, copeptin concentrations were significantly associated with severely reduced right heart function (TAPSE?<?18?mm) within a multivariate logistic regression model (copeptin: odds ratio: 0.94; 95% confidence interval: 0.911?0.975; P?=?0.001).

Conclusions: This study demonstrates that the novel biomarker copeptin reflects longitudinal right heart function assessed by standardized transthoracic echocardiography compared with NT-proBNP.
VL  - 58
CY  - London
SP  - 270
N1  - Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich. *** This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
AV  - public
EP  - 279
ER  -