eprintid: 30223
rev_number: 15
eprint_status: archive
userid: 3730
dir: disk0/00/03/02/23
datestamp: 2021-07-16 08:16:48
lastmod: 2022-02-12 11:00:30
status_changed: 2021-07-16 08:16:48
type: article
metadata_visibility: show
creators_name: Harbrücker, Melissa
creators_name: Natale, Michèle
creators_name: Kim, Seung-Hyun
creators_name: Müller, Julian
creators_name: Ansari, Uzair
creators_name: Huseynov, Aydin
creators_name: Zworowsky, Max von
creators_name: Borggrefe, Martin
creators_name: Hoffmann, Ursula
creators_name: Lang, Siegfried
creators_name: Fatar, Marc
creators_name: Roth, Thomas
creators_name: Kittel, Maximilian
creators_name: Bertsch, Thomas
creators_name: Akin, Ibrahim
creators_name: Behnes, Michael
title: Copeptin reliably reflects longitudinal right ventricular function
subjects: ddc-610
divisions: i-62200
keywords: Copeptin, diagnosis, right heart failure, right heart function, right ventricle
note: Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich. *** This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
abstract: Background: Data is limited evaluating novel biomarkers in right ventricular dysfunction. Normal right heart function improves the prognosis of patients with heart failure. Therefore, this study investigates the association between the novel biomarker copeptin and right heart function compared to NT-proBNP.

Methods: Patients undergoing routine echocardiography were enrolled prospectively. Right ventricular function was assessed by tricuspid annular plane systolic excursion (TAPSE) and further right ventricular and atrial parameters. Exclusion criteria were age under 18 years, left ventricular ejection fraction < 50% and moderate to severe valvular heart disease. Blood samples were taken for biomarker measurements within 72 h of echocardiography.

Results: Ninety-one patients were included. Median values of copeptin increased significantly according to decreasing values of TAPSE (P = 0.001; right heart function grade I: tricuspid annular plane systolic excursion; TAPSE > 24 mm: 5.20 pmol/L; grade II: TAPSE 18–24 mm: 8.10 pmol/L; grade III: TAPSE < 18 mm: 26.50 pmol/L). Copeptin concentrations were able to discriminate patients with decreased right heart function defined as TAPSE < 18 mm (area under the curves [AUC]: copeptin: 0.793; P = 0.001; NT-proBNP: 0.805; P = 0.0001). Within a multivariable linear regression model, copeptin was independently associated with TAPSE (copeptin: T: –4.43; P = 0.0001; NT-proBNP: T: –1.21; P = 0.23). Finally, copeptin concentrations were significantly associated with severely reduced right heart function (TAPSE < 18 mm) within a multivariate logistic regression model (copeptin: odds ratio: 0.94; 95% confidence interval: 0.911–0.975; P = 0.001).

Conclusions: This study demonstrates that the novel biomarker copeptin reflects longitudinal right heart function assessed by standardized transthoracic echocardiography compared with NT-proBNP.
date: 2021
publisher: Sage
id_scheme: DOI
id_number: 10.11588/heidok.00030223
official_url: https://doi.org/10.1177/0004563221989364
ppn_swb: 1787334341
own_urn: urn:nbn:de:bsz:16-heidok-302236
language: eng
bibsort: HARBRUCKERCOPEPTINRE2021
full_text_status: public
publication: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
volume: 58
number: 4
place_of_pub: London
pagerange: 270-279
issn: 0004-5632 (Druck-Ausg.), 1758-1001 (Online-Ausg.)
edition: Zweitveröffentlichung
citation:   Harbrücker, Melissa ; Natale, Michèle ; Kim, Seung-Hyun ; Müller, Julian ; Ansari, Uzair ; Huseynov, Aydin ; Zworowsky, Max von ; Borggrefe, Martin ; Hoffmann, Ursula ; Lang, Siegfried ; Fatar, Marc ; Roth, Thomas ; Kittel, Maximilian ; Bertsch, Thomas ; Akin, Ibrahim ; Behnes, Michael  (2021) Copeptin reliably reflects longitudinal right ventricular function.  Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 58 (4).  pp. 270-279.  ISSN 0004-5632 (Druck-Ausg.), 1758-1001 (Online-Ausg.)     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/30223/1/10.1177_0004563221989364.pdf