eprintid: 30387
rev_number: 18
eprint_status: archive
userid: 6116
dir: disk0/00/03/03/87
datestamp: 2021-08-24 12:45:04
lastmod: 2022-08-29 08:42:03
status_changed: 2021-08-24 12:45:04
type: doctoralThesis
metadata_visibility: show
creators_name: Abd El Hay, Muad Yusuf
title: The role of TRPV1 and TRPM2 in warm temperature detection
subjects: 570
divisions: 140001
adv_faculty: af-14
abstract: Ambient temperature is detected via specialized sensory nerve ending in the skin. The transduction of thermal stimuli into action potentials relies on the activity of temperature sensitive ion channels located in the membranes of sensory nerve endings. The molecular mechanism of cold and heat transduction is well characterized. However, the ion channels responsible for the detection of innocuous warmth are still a matter of debate.

TRPV1 and TRPM2 are temperature sensitive cation channels belonging to the family of transient receptor potential (TRP) channels. Recent findings implicate a role for both TRPV1 and TRPM2 in warm-temperature detection. Cellular data from animals lacking TRPV1 and TRPM2 or pharmacological inhibition support this idea. However, in vivo assessment of TRPV1- and TRPM2-involvement in temperature detection yields seemingly contradictory results. 

In this study, the role of TRPV1 and TRPM2 in warmth detection was evaluated in vitro and in vivo under comparable conditions.
date: 2022
id_scheme: DOI
id_number: 10.11588/heidok.00030387
ppn_swb: 1815236736
own_urn: urn:nbn:de:bsz:16-heidok-303879
date_accepted: 2021-06-17
advisor: HASH(0x556120875878)
language: eng
bibsort: ABDELHAYMUTHEROLEOFT2022
full_text_status: public
place_of_pub: Heidelberg
citation:   Abd El Hay, Muad Yusuf  (2022) The role of TRPV1 and TRPM2 in warm temperature detection.  [Dissertation]     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/30387/1/thesis-revised2.pdf