<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Colorectal cancer risk prediction\r\nand risk-adapted colorectal cancer screening\r\nin patients with diabetes mellitus"^^ . "Colorectal cancer is currently the third most common and the second most deadly of all cancers.\r\nDespite the success of global colorectal cancer screening programs in reduction of both\r\nincidence and mortality, in recent decades the incidence in young individuals, particularly before\r\nthe age of 50, has risen in several countries. Resultantly, there is a call for colorectal cancer\r\nscreening programs to alter screening recommendation and identify risk factors that make young\r\npeople susceptible. Diabetes is a disease that has also been rising in young people in recent\r\ndecades. Additionally, diabetes shares several risk factors with colorectal cancer and has been\r\nassociated with colorectal cancer in some studies. Hence, it becomes increasingly important to\r\ndetermine if diabetic patients are at increased risk and if they should be directed for an earlier\r\nscreening than the general population.\r\nThis study aimed to investigate the associations between diabetes and early-onset and late-onset\r\ncolorectal cancer and determine what effect age of diabetes diagnosis, family history of\r\ncolorectal cancer, and sex have on these associations. In addition, if diabetic patients are at\r\nincreased risk of colorectal cancer, it aimed to provide evidence-based risk-adapted screening\r\nages in diabetic patients with and without a family history of colorectal cancer, given that\r\ndiabetes has yet to be mentioned in global screening guidelines.\r\nThe analysis was conducted using the Swedish family-cancer datasets, the world’s largest of\r\ntheir kinds with record linkage to the Swedish Inpatient and Outpatient Registers. The study\r\npopulation consisted of 12,614,256 individuals with valid genealogical information (at least one\r\nfirst-degree relatives) and up to 52 years of follow-up spanning from 1964 to 2015. Among the\r\n\r\n12.6 million individuals, 559,375 cases of diabetes and 162,226 cases of colorectal cancer were\r\nidentified. Standardized incidence ratios, lifetime cumulative risk (age 0 to 79), and 10-year\r\ncumulative risk of colorectal cancer in diabetic patients with and without a family history of\r\ncolorectal cancer were calculated. Both family and personal disease histories were ascertained\r\nusing a dynamic (time-dependent) method, in which individuals were treated as cases only from\r\ntheir age at diagnosis onwards.\r\nIt was observed that diabetic patients are at an increased risk of colorectal cancer, particularly\r\nearly-onset colorectal cancer and that the magnitude of this association was similar to that of\r\nhaving a first-degree relative with colorectal cancer. This risk was further elevated in diabetic\r\npatients with an additional family history of colorectal cancer with nearly 7 times the risk of\r\ncolorectal cancer compared to those in the general population with no diabetes and no family\r\nhistory of colorectal cancer. Building on these findings, the study provided risk-adapted ages of\r\ninitial colorectal cancer screening for diabetic patients with and without a family history of\r\ncolorectal cancer. It was found that diabetic patients reached the population level of risk several\r\nyears earlier irrespective of the benchmark age of screening in the population (age 45, 50, 55 or\r\n60).\r\nThe results regarding risk of colorectal cancer in diabetic patients provide clinically-relevant and\r\nevidence-based data designed for real-time counselling of diabetic patients who are at an\r\nincreased risk for early-onset colorectal cancer. The findings could help physicians provide\r\npersonalized screening recommendation for diabetic patients and at the very least make patients\r\nwary of their increased risk so they can make lifestyle changes accordingly. Overall, irrespective\r\nof the specific application, the findings carry strong potential in impacting the management of\r\ndiabetes, especially in young patients who are not targeted by colorectal cancer screening."^^ . "2021" . . . . . . . "Uzair"^^ . "Ali Khan"^^ . "Uzair Ali Khan"^^ . . . . . . "Colorectal cancer risk prediction\r\nand risk-adapted colorectal cancer screening\r\nin patients with diabetes mellitus (PDF)"^^ . . . "AliKhan_Uzair_24_07_1994_Dissertation.pdf"^^ . . . "Colorectal cancer risk prediction\r\nand risk-adapted colorectal cancer screening\r\nin patients with diabetes mellitus (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . 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