<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Oxygen Effects in (FLASH-) Radiotherapy on a Radiochemical and Genetic Level"^^ . "In radiotherapy, oxygen acts as strong radiosensitizer and alters cellular response to radiation drastically. Especially, the effect of the so-called FLASH radiotherapy,\r\nwhich applies high dose rates above 40 Gy/s to spare healthy tissue from radiation damage, is influenced by oxygen. At high O2 levels the protective effect of FLASH is decreased in vivo. The underlying mechanisms are not completely understood yet. In this thesis, oxygen effects were investigated on (i) a radiochemical level by oxygen depletion measurements in water phantoms and together with cancer cells, (ii)on a genetic level developing a novel analysis method on gene expression patterns and (iii) on a mechanistic, radical scavenging level by modulating cellular defense. It was found, that a popular hypothesis for explaining the FLASH effect, the oxygen depletion hypothesis, cannot be solely responsible for the observed altered cellular response after FLASH through radiation induced hypoxia alone. However, radical concentrations are highly dependent on dose rate and beam pulse structure implying potential biological impact. Radical scavenging systems in cells were found to be altered using SOD-mimicking CuL/FeL compounds leading to a decrease of metastatic potential. The results strengthen the link between FLASH effects and radical levels, influenced by radical scavenging systems in cancer cells and oxygen conditions."^^ . "2022" . . . . . . . "Jeannette"^^ . "Jansen"^^ . "Jeannette Jansen"^^ . . . . . . "Oxygen Effects in (FLASH-) Radiotherapy on a Radiochemical and Genetic Level (PDF)"^^ . . . "Dissertation_Jeannette_Jansen_Dez_2021_PDFA.pdf"^^ . . . "Oxygen Effects in (FLASH-) Radiotherapy on a Radiochemical and Genetic Level (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Oxygen Effects in (FLASH-) Radiotherapy on a Radiochemical and Genetic Level (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Oxygen Effects in (FLASH-) Radiotherapy on a Radiochemical and Genetic Level (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Oxygen Effects in (FLASH-) Radiotherapy on a Radiochemical and Genetic Level (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #31184 \n\nOxygen Effects in (FLASH-) Radiotherapy on a Radiochemical and Genetic Level\n\n" . "text/html" . . . "530 Physik"@de . "530 Physics"@en . .