<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "NCK1/2 are specific mediators of migration in Pericytes and promising targets in ischemic retinopathies"^^ . "The particular focus of my dissertation is on pericytes which are mural cells that surround capillaries and control angiogenesis and capillary barrier function. I investigate endothelial cell-derived platelet-derived growth factor-B (PDGF-B) signaling during sprouting angiogenesis in health and disease. With this, I show that “activated” α-SMA-expressing pericytes cover angiogenic sprouts and pathological neovascular tufts (NVTs) in a mouse model of oxygen-induced retinopathy. By genetic lineage tracing experiments, this work demonstrates that pericytes acquire α-SMA expression during pathological NVT formation. Pericyte depletion through inducible endothelial-specific knockout of the ligand Pdgf-b decreases this NVT formation, but also impairs revascularization. Moreover, I demonstrate that loss of Nck1 and Nck2 in mural cells prevents NVT formation and vascular leakage and promotes revascularization, suggesting NCK signaling as a potential target for the treatment of retinopathies."^^ . "2022" . . . . . . . "Steffen Emil"^^ . "Künzel"^^ . "Steffen Emil Künzel"^^ . . . . . . "NCK1/2 are specific mediators of migration in Pericytes and promising targets in ischemic retinopathies (PDF)"^^ . . . "Dissertation_SteffenEKuenzel_2022.pdf"^^ . . . "NCK1/2 are specific mediators of migration in Pericytes and promising targets in ischemic retinopathies (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "NCK1/2 are specific mediators of migration in Pericytes and promising targets in ischemic retinopathies (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "NCK1/2 are specific mediators of migration in Pericytes and promising targets in ischemic retinopathies (Other)"^^ . . . . . . "preview.jpg"^^ . . . "NCK1/2 are specific mediators of migration in Pericytes and promising targets in ischemic retinopathies (Other)"^^ . . . . . . "medium.jpg"^^ . . . "NCK1/2 are specific mediators of migration in Pericytes and promising targets in ischemic retinopathies (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #31721 \n\nNCK1/2 are specific mediators of migration in Pericytes and promising targets in ischemic retinopathies\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .