TY  - GEN
Y1  - 2022///
TI  - NCK1/2 are specific mediators of migration in Pericytes and promising targets in ischemic retinopathies
CY  - Heidelberg
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/31721/
N2  - The particular focus of my dissertation is on pericytes which are mural cells that surround capillaries and control angiogenesis and capillary barrier function. I investigate endothelial cell-derived platelet-derived growth factor-B (PDGF-B) signaling during sprouting angiogenesis in health and disease. With this, I show that ?activated? ?-SMA-expressing pericytes cover angiogenic sprouts and pathological neovascular tufts (NVTs) in a mouse model of oxygen-induced retinopathy. By genetic lineage tracing experiments, this work demonstrates that pericytes acquire ?-SMA expression during pathological NVT formation. Pericyte depletion through inducible endothelial-specific knockout of the ligand Pdgf-b decreases this NVT formation, but also impairs revascularization. Moreover, I demonstrate that loss of Nck1 and Nck2 in mural cells prevents NVT formation and vascular leakage and promotes revascularization, suggesting NCK signaling as a potential target for the treatment of retinopathies.
ID  - heidok31721
A1  - Künzel, Steffen Emil
AV  - public
ER  -