<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Novel Molecular Mechanisms of TSC22D4 action in development of Diabetes Mellitus"^^ . "The pathogenesis of Type 2 Diabetes (T2D) manifests itself with elevated blood glucose and insulin levels.\r\nAt the molecular level, dysregulations in the insulin signaling pathway cause disruptive cellular processes\r\nmodulated by distinct regulators. Akt plays a key role in the insulin signaling cascade regulating glucose and\r\nlipid metabolism, cell survival and proliferation. In my Ph.D. project, I identified Transforming Growth Factor\r\nβ1 (TGFβ1) Stimulated Clone 22 D4 (TSC22D4) as a novel Akt-interacting protein. TSC22D4 interacts specifically\r\nwith Akt1 via its D2 domain, which is located in the intrinsically disordered region of TSC22D4. Starvation or\r\nenergy deprivation promotes TSC22D4-Akt1 interaction, while refeeding mice or stimulating cells with glucose\r\nand insulin impairs the interaction. Having identified the interaction site of TSC22D4 with Akt1, we produced\r\nthe D2+TSC allele which constitutively interacts with Akt1, independent of nutrient availability. The strong\r\ninteraction of TSC22D4 and Akt1 (via D2+TSC allele) improves glucose handling, insulin sensitivity and lipid\r\naccumulation in AAV-transduced TSC22D4hep-/- mice. Altogether, TSC22D4 plays a role in regulating insulin\r\nsignaling via interacting Akt and contributes to its function on glucose and lipid metabolism."^^ . "2022" . . . . . . . "Sevgican"^^ . "Demir"^^ . "Sevgican Demir"^^ . . . . . . "Novel Molecular Mechanisms of TSC22D4 action in development of Diabetes Mellitus (PDF)"^^ . . . "PhD Thesis_Sevgican Demir_for publication.pdf"^^ . . . "Novel Molecular Mechanisms of TSC22D4 action in development of Diabetes Mellitus (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Novel Molecular Mechanisms of TSC22D4 action in development of Diabetes Mellitus (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Novel Molecular Mechanisms of TSC22D4 action in development of Diabetes Mellitus (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Novel Molecular Mechanisms of TSC22D4 action in development of Diabetes Mellitus (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Novel Molecular Mechanisms of TSC22D4 action in development of Diabetes Mellitus (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #32543 \n\nNovel Molecular Mechanisms of TSC22D4 action in development of Diabetes Mellitus\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .