<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "An evaluation of mathematical models for stem cell dynamics in neurogenesis"^^ . "The dynamics of adult neurogenesis in the ventricular-subventricular zone are yet to be fully understood. In particular, how the pool of neural stem cells (NSCs), in active and quiescent states, is maintained while undergoing ageing effects. Mathematical modelling of biological systems can help to gain insight into such dynamics, to discover dependencies that may not be obvious purely from the data. This thesis evaluates different models of ordinary differential equations to describe those dynamics. First, a simplified, macroscopic model of neurogenesis based on an existing model of active and quiescent NSCs has been developed via a steady-state for the fraction of active NSCs among all NSCs. It was used to relate the parameters of the two former models via the macroscopic model, that does not inherently distinguish between active and quiescent cell states. Secondly, two neurogenesis model versions with constant and time-dependent self-renewal are compared and parameter estimation is applied to the macroscopic model. Although the NSC dynamics can be observed with all models, the macroscopic lense results in non-identifiable microscopic parameters. Furthermore, the model cannot capture the fraction of active NSCs among NSCs, as expected, due to the single equation it is defined by."^^ . "2023" . . . . . . . "Maria Anita"^^ . "Stickel"^^ . "Maria Anita Stickel"^^ . . . . . . "An evaluation of mathematical models for stem cell dynamics in neurogenesis (PDF)"^^ . . . "BachelorThesisMariaStickel.pdf"^^ . . . "An evaluation of mathematical models for stem cell dynamics in neurogenesis (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "An evaluation of mathematical models for stem cell dynamics in neurogenesis (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "An evaluation of mathematical models for stem cell dynamics in neurogenesis (Other)"^^ . . . . . . "preview.jpg"^^ . . . "An evaluation of mathematical models for stem cell dynamics in neurogenesis (Other)"^^ . . . . . . "medium.jpg"^^ . . . "An evaluation of mathematical models for stem cell dynamics in neurogenesis (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #32851 \n\nAn evaluation of mathematical models for stem cell dynamics in neurogenesis\n\n" . "text/html" . . . "500 Naturwissenschaften und Mathematik"@de . "500 Natural sciences and mathematics"@en . . . "510 Mathematik"@de . "510 Mathematics"@en . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .