<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Mathematical modeling of Lynch syndrome carcinogenesis"^^ . "Cancer is one of the leading causes of disease-related death worldwide. In recent years, large amounts of data on cancer genetics and molecular characteristics have become available and accumulated with increasing speed. However, the current understanding of cancer as a disease is still limited by the lack of suitable models that allow interpreting these data in proper ways. Thus, the highly interdisciplinary research field of mathematical oncology has evolved to use mathematics, modeling, and simulations to study cancer with the overall goal to improve clinical patient care.\r\n\r\nThis dissertation aims at developing mathematical models and tools for different spatial scales of cancer development at the example of colorectal cancer in Lynch syndrome, the most common inherited colorectal cancer predisposition syndrome. We derive model-driven approaches for carcinogenesis at the DNA, cell, and crypt level, as well as data-driven methods for cancer-immune interactions at the DNA level and for the evaluation of diagnostic procedures at the Lynch syndrome population level. The developed models present an important step toward an improved understanding of hereditary cancer as a disease aiming at rapid implementation into clinical management guidelines and into the development of novel, innovative approaches for prevention and treatment."^^ . "2023" . . . . . . . "Saskia"^^ . "Haupt"^^ . "Saskia Haupt"^^ . . . . . . "Mathematical modeling of Lynch syndrome carcinogenesis (PDF)"^^ . . . "Dissertation_Saskia_Haupt.pdf"^^ . . . "Mathematical modeling of Lynch syndrome carcinogenesis (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Mathematical modeling of Lynch syndrome carcinogenesis (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Mathematical modeling of Lynch syndrome carcinogenesis (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Mathematical modeling of Lynch syndrome carcinogenesis (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Mathematical modeling of Lynch syndrome carcinogenesis (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #33194 \n\nMathematical modeling of Lynch syndrome carcinogenesis\n\n" . "text/html" . . . "500 Naturwissenschaften und Mathematik"@de . "500 Natural sciences and mathematics"@en . . . "510 Mathematik"@de . "510 Mathematics"@en . . . "600 Technik, Medizin, angewandte Wissenschaften"@de . "600 Technology (Applied sciences)"@en . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .