TY  - JOUR
SP  - 1038
SN  - 0284-1851 (Druck-Ausg.); 1600-0455 (Online-Ausg.)
TI  - Reproducibility of pulmonary magnetic resonance angiography in adults with muco-obstructive pulmonary disease
ID  - heidok33229
AV  - public
N1  - Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich. *** This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively
N2  - Background
Recent studies support magnetic resonance angiography (MRA) as a diagnostic tool for pulmonary arterial disease.
Purpose
To determine MRA image quality and reproducibility, and the dependence of MRA image quality and reproducibility on disease severity in patients with chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF).
Material and Methods
Twenty patients with COPD (mean age 66.5?±?8.9 years; FEV1%?=?42.0?±?13.3%) and 15 with CF (mean age 29.3?±?9.3 years; FEV1%?=?66.6?±?15.8%) underwent morpho-functional chest magnetic resonance imaging (MRI) including time-resolved MRA twice one month apart (MRI1, MRI2), and COPD patients underwent non-contrast computed tomography (CT). Image quality was assessed visually using standardized subjective 5-point scales. Contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR) were measured by regions of interest. Disease severity was determined by spirometry, a well-evaluated chest MRI score, and by computational CT emphysema index (EI) for COPD.
Results
Subjective image quality was diagnostic for all MRA at MRI1 and MRI2 (mean score?=?4.7?±?0.6). CNR and SNR were 4 43.8?±?8.7 and 50.5?±?8.7, respectively. Neither image quality score nor CNR or SNR correlated with FEV1% or chest MRI score for COPD and CF (r?=?0.239?0.248). CNR and SNR did not change from MRI1 to MRI2 (P?=?0.434?0.995). Further, insignificant differences in CNR and SNR between MRA at MRI1 and MRI2 did not correlate with FEV1% nor chest MRI score in COPD and CF (r?=??0.238?0.183), nor with EI in COPD (r?=?0.100?0.111).
Conclusion
MRA achieved diagnostic quality in COPD and CF patients and was highly reproducible irrespective of disease severity. This supports MRA as a robust alternative to CT in patients with underlying muco-obstructive lung disease.
EP  - 1046
JF  - Acta Radiologica
A1  - Wucherpfennig, Lena
A1  - Triphan, Simon MF
A1  - Weinheimer, Oliver
A1  - Eichinger, Monika
A1  - Wege, Sabine
A1  - Eberhardt, Ralf
A1  - Puderbach, Michael U
A1  - Kauczor, Hans-Ulrich
A1  - Heussel, Claus P
A1  - Heussel, Gudula
A1  - Wielpütz, Mark O
Y1  - 2023///
VL  - 64
PB  - Sage
UR  - https://doi.org/10.1177/02841851221111486
CY  - [London]
KW  - Magnetic resonance angiography
KW  -  functional imaging
KW  -  cystic fibrosis
KW  -  chronic obstructive pulmonary disease
IS  - 3
ER  -