eprintid: 33229
rev_number: 13
eprint_status: archive
userid: 5878
dir: disk0/00/03/32/29
datestamp: 2023-05-05 10:46:42
lastmod: 2023-07-27 14:30:00
status_changed: 2023-05-05 10:46:42
type: article
metadata_visibility: show
creators_name: Wucherpfennig, Lena
creators_name: Triphan, Simon MF
creators_name: Weinheimer, Oliver
creators_name: Eichinger, Monika
creators_name: Wege, Sabine
creators_name: Eberhardt, Ralf
creators_name: Puderbach, Michael U
creators_name: Kauczor, Hans-Ulrich
creators_name: Heussel, Claus P
creators_name: Heussel, Gudula
creators_name: Wielpütz, Mark O
title: Reproducibility of pulmonary magnetic resonance angiography in adults with muco-obstructive pulmonary disease
subjects: 610
divisions: 942000
divisions: 999999
keywords: Magnetic resonance angiography, functional imaging, cystic fibrosis, chronic obstructive pulmonary disease
note: Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich. *** This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively
abstract: Background
Recent studies support magnetic resonance angiography (MRA) as a diagnostic tool for pulmonary arterial disease.
Purpose
To determine MRA image quality and reproducibility, and the dependence of MRA image quality and reproducibility on disease severity in patients with chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF).
Material and Methods
Twenty patients with COPD (mean age 66.5 ± 8.9 years; FEV1% = 42.0 ± 13.3%) and 15 with CF (mean age 29.3 ± 9.3 years; FEV1% = 66.6 ± 15.8%) underwent morpho-functional chest magnetic resonance imaging (MRI) including time-resolved MRA twice one month apart (MRI1, MRI2), and COPD patients underwent non-contrast computed tomography (CT). Image quality was assessed visually using standardized subjective 5-point scales. Contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR) were measured by regions of interest. Disease severity was determined by spirometry, a well-evaluated chest MRI score, and by computational CT emphysema index (EI) for COPD.
Results
Subjective image quality was diagnostic for all MRA at MRI1 and MRI2 (mean score = 4.7 ± 0.6). CNR and SNR were 4 43.8 ± 8.7 and 50.5 ± 8.7, respectively. Neither image quality score nor CNR or SNR correlated with FEV1% or chest MRI score for COPD and CF (r = 0.239–0.248). CNR and SNR did not change from MRI1 to MRI2 (P = 0.434–0.995). Further, insignificant differences in CNR and SNR between MRA at MRI1 and MRI2 did not correlate with FEV1% nor chest MRI score in COPD and CF (r = −0.238–0.183), nor with EI in COPD (r = 0.100–0.111).
Conclusion
MRA achieved diagnostic quality in COPD and CF patients and was highly reproducible irrespective of disease severity. This supports MRA as a robust alternative to CT in patients with underlying muco-obstructive lung disease.
date: 2023
publisher: Sage
id_scheme: DOI
id_number: 10.11588/heidok.00033229
official_url: https://doi.org/10.1177/02841851221111486
ppn_swb: 185382027X
own_urn: urn:nbn:de:bsz:16-heidok-332298
language: eng
bibsort: WUCHERPFENREPRODUCIB2023
full_text_status: public
publication: Acta Radiologica
volume: 64
number: 3
place_of_pub: [London]
pagerange: 1038-1046
issn: 0284-1851 (Druck-Ausg.); 1600-0455 (Online-Ausg.)
edition: Zweitveröffentlichung
citation:   Wucherpfennig, Lena ; Triphan, Simon MF ; Weinheimer, Oliver ; Eichinger, Monika ; Wege, Sabine ; Eberhardt, Ralf ; Puderbach, Michael U ; Kauczor, Hans-Ulrich ; Heussel, Claus P ; Heussel, Gudula ; Wielpütz, Mark O  (2023) Reproducibility of pulmonary magnetic resonance angiography in adults with muco-obstructive pulmonary disease.  Acta Radiologica, 64 (3).  pp. 1038-1046.  ISSN 0284-1851 (Druck-Ausg.); 1600-0455 (Online-Ausg.)     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/33229/1/10.1177_02841851221111486.pdf