TY  - JOUR
SP  - 2111
N2  - Background
Low attenuation volume percentage (LAV%) has been identified as a quantitative imaging biomarker for emphysema with good correlation with spirometry. The influence of intravenous contrast agent on LAV% and its correlation with spirometry is not well known.
Purpose
To evaluate the influence of intravenous contrast agent on artificial intelligence (AI)-based LAV% in correlation with spirometric Tiffeneau-Pinelli Index (TI).
Material and Methods
In a retrospective study, two groups of 47 patients (mean age 68.04?±?12.64 and 67.89?±?11.54 years) with either non-enhanced chest computed tomography (CT) or contrast-enhanced CT were compared. Using an AI-based software, LAV% was quantified using a threshold <?950 HU. TI was calculated from spirometry and pathologic airway obstruction was considered with a TI <70. The effect of contrast agent on LAV% and the relationship between TI and LAV% was analyzed. Correlation coefficients between TI and LAV% were compared for both groups.
Results
Patients with non-enhanced CT had a mean LAV% of 9.07?±?7.53. Of them, 22 patients had a TI <70% and 25 patients a TI ?70%. Patients with contrast-enhanced CT had a mean LAV% of 6.54?±?4.62. Of them, 20 patients had a TI <70% and 27 patients had a TI ?70%. Contrast agent did not show a major effect on LAV% (P?=?0.099) and the relationship between TI and LAV% (P?=?0.88). In both groups, a significant correlation between TI and LAV% was found (??=??0.317 for non-enhanced CT; ??=??0.514 for contrast-enhanced CT). Difference between correlation coefficients was insignificant.
Conclusion
Our findings suggest that contrast agent does not influence LAV% nor its correlation with TI.
Y1  - 2023///
A1  - Wiedbrauck, Damian
A1  - Karczewski, Maciej
A1  - Schoenberg, Stefan O
A1  - Fink, Christian
A1  - Kayed, Hany
UR  - https://doi.org/10.1177/02841851231165486
SN  - 0284-1851 (Druck-Ausg.); 1600-0455 (Online-Ausg.)
CY  - [London]
N1  - Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich. *** This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
EP  - 2117
IS  - 6
VL  - 64
ID  - heidok33324
PB  - Sage
JF  - Acta Radiologica
TI  - Influence of contrast agent on artificial intelligence-based CT low attenuation volume percentage measurement
AV  - public
ER  -