<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Leveraging elasticity theory to calculate cell forces:\r\nFrom analytical insights to machine learning"^^ . "Living cells possess capabilities to detect and respond to mechanical features of their surroundings. In traction force microscopy, the traction of cells on an elastic substrate is made visible by observing substrate deformation as measured by the movement of embedded marker beads. Describing the substrates by means of elasticity theory, we can calculate the adhesive forces, improving our understanding of cellular function and behavior. In this dissertation, I combine analytical solutions with numerical methods and machine learning techniques to improve traction prediction in a range of experimental applications. I describe how to include the normal traction component in regularization-based Fourier approaches, which I apply to experimental data. I compare the dominant strategies for traction reconstruction, the direct method and inverse, regularization-based approaches and find, that the latter are more precise while the former is more stress resilient to noise. I find that a point-force based reconstruction can be used to study the force balance evolution in response to microneedle pulling showing a transition from a dipolar into a monopolar force arrangement. Finally, I show how a conditional invertible neural network not only reconstructs adhesive areas more localized, but also reveals spatial correlations and variations in reliability of traction reconstructions."^^ . "2023" . . . . . . . "Johannes Wolfram"^^ . "Blumberg"^^ . "Johannes Wolfram Blumberg"^^ . . . . . . "Leveraging elasticity theory to calculate cell forces:\r\nFrom analytical insights to machine learning (PDF)"^^ . . . "DissertationJohannesBlumbergFinal_600dpi.pdf"^^ . . . "Leveraging elasticity theory to calculate cell forces:\r\nFrom analytical insights to machine learning (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Leveraging elasticity theory to calculate cell forces:\r\nFrom analytical insights to machine learning (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Leveraging elasticity theory to calculate cell forces:\r\nFrom analytical insights to machine learning (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Leveraging elasticity theory to calculate cell forces:\r\nFrom analytical insights to machine learning (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Leveraging elasticity theory to calculate cell forces:\r\nFrom analytical insights to machine learning (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #33913 \n\nLeveraging elasticity theory to calculate cell forces: \nFrom analytical insights to machine learning\n\n" . "text/html" . . . "530 Physik"@de . "530 Physics"@en . .