title: Development and investigation of an integrated preclinical PET-OT system concept
creator: Pazos Clemens, Luis
description: Efforts towards the development of a detector system designed for simultaneous optical  and nuclear imaging, i.e. combining fluorescence/bioluminescence techniques with  PET/SPECT modalities, have started over a decade ago. Given the potential that would  be introduced by the capacity of simultaneously detecting gamma-rays and optical-  probe photons, a concept for an integrated system being capable of achieving such task  was developed in this work. The blueprint for an integrated preclinical PET-OT system  consisting of detector modules that combine monolithic scintillating crystals with  plenoptic detectors is presented. Each module of this system is specifically composed of  a 25x25x25mm LYSO crystal with two 8x8-channel photosensors of matching 2D size  coupled to its back face and to another lateral face of the crystal in a perpendicular dual-  readout configuration. The plenoptic detectors consist of a CMOS flat sensor of  corresponding 2D size with a microlens array attached to them. A simulation and  reconstruction framework for the investigation of monolithic-detector PET systems was  developed for the conception and analysis of the proposed system. Within this  framework, two alternative algorithms required for the operation of monolithic-detector  PET systems were developed respectively based on a k-nearest neighbours and a  convolutional neural network approach. The POI estimation FWHM-resolution of the  former was found to be 0.68mm, 0.66mm and 0.52mm in the x, y and z dimensions  respectively for the monolithic-detector module in the proposed system. The latter  presented a POI estimation FWHM-resolution of 0.42mm, 0.41mm and 0.49mm in the  x, y and z dimensions respectively. The crystal depth, the number of crystal faces to  which a photosensor is coupled and the number of channels per photosensor were  optimised in order to reach the final proposed design.
date: 2023
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/34131/1/PhD_THESIS_print.pdf
identifier: DOI:10.11588/heidok.00034131
identifier: urn:nbn:de:bsz:16-heidok-341319
identifier:   Pazos Clemens, Luis  (2023) Development and investigation of an integrated preclinical PET-OT system concept.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/34131/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng