<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Development and investigation of an integrated preclinical PET-OT system concept"^^ . "Efforts towards the development of a detector system designed for simultaneous optical\r\nand nuclear imaging, i.e. combining fluorescence/bioluminescence techniques with\r\nPET/SPECT modalities, have started over a decade ago. Given the potential that would\r\nbe introduced by the capacity of simultaneously detecting gamma-rays and optical-\r\nprobe photons, a concept for an integrated system being capable of achieving such task\r\nwas developed in this work. The blueprint for an integrated preclinical PET-OT system\r\nconsisting of detector modules that combine monolithic scintillating crystals with\r\nplenoptic detectors is presented. Each module of this system is specifically composed of\r\na 25x25x25mm LYSO crystal with two 8x8-channel photosensors of matching 2D size\r\ncoupled to its back face and to another lateral face of the crystal in a perpendicular dual-\r\nreadout configuration. The plenoptic detectors consist of a CMOS flat sensor of\r\ncorresponding 2D size with a microlens array attached to them. A simulation and\r\nreconstruction framework for the investigation of monolithic-detector PET systems was\r\ndeveloped for the conception and analysis of the proposed system. Within this\r\nframework, two alternative algorithms required for the operation of monolithic-detector\r\nPET systems were developed respectively based on a k-nearest neighbours and a\r\nconvolutional neural network approach. The POI estimation FWHM-resolution of the\r\nformer was found to be 0.68mm, 0.66mm and 0.52mm in the x, y and z dimensions\r\nrespectively for the monolithic-detector module in the proposed system. The latter\r\npresented a POI estimation FWHM-resolution of 0.42mm, 0.41mm and 0.49mm in the\r\nx, y and z dimensions respectively. The crystal depth, the number of crystal faces to\r\nwhich a photosensor is coupled and the number of channels per photosensor were\r\noptimised in order to reach the final proposed design."^^ . "2023" . . . . . . . "Luis"^^ . "Pazos Clemens"^^ . "Luis Pazos Clemens"^^ . . . . . . "Development and investigation of an integrated preclinical PET-OT system concept (PDF)"^^ . . . "PhD_THESIS_print.pdf"^^ . . . "Development and investigation of an integrated preclinical PET-OT system concept (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Development and investigation of an integrated preclinical PET-OT system concept (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Development and investigation of an integrated preclinical PET-OT system concept (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Development and investigation of an integrated preclinical PET-OT system concept (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Development and investigation of an integrated preclinical PET-OT system concept (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #34131 \n\nDevelopment and investigation of an integrated preclinical PET-OT system concept\n\n" . "text/html" . .