eprintid: 34131
rev_number: 14
eprint_status: archive
userid: 7791
dir: disk0/00/03/41/31
datestamp: 2023-12-14 10:39:24
lastmod: 2024-02-06 08:13:52
status_changed: 2023-12-14 10:39:24
type: doctoralThesis
metadata_visibility: show
creators_name: Pazos Clemens, Luis
title: Development and investigation of an integrated preclinical PET-OT system concept
divisions: i-130001
divisions: i-850300
adv_faculty: af-13
abstract: Efforts towards the development of a detector system designed for simultaneous optical
and nuclear imaging, i.e. combining fluorescence/bioluminescence techniques with
PET/SPECT modalities, have started over a decade ago. Given the potential that would
be introduced by the capacity of simultaneously detecting gamma-rays and optical-
probe photons, a concept for an integrated system being capable of achieving such task
was developed in this work. The blueprint for an integrated preclinical PET-OT system
consisting of detector modules that combine monolithic scintillating crystals with
plenoptic detectors is presented. Each module of this system is specifically composed of
a 25x25x25mm LYSO crystal with two 8x8-channel photosensors of matching 2D size
coupled to its back face and to another lateral face of the crystal in a perpendicular dual-
readout configuration. The plenoptic detectors consist of a CMOS flat sensor of
corresponding 2D size with a microlens array attached to them. A simulation and
reconstruction framework for the investigation of monolithic-detector PET systems was
developed for the conception and analysis of the proposed system. Within this
framework, two alternative algorithms required for the operation of monolithic-detector
PET systems were developed respectively based on a k-nearest neighbours and a
convolutional neural network approach. The POI estimation FWHM-resolution of the
former was found to be 0.68mm, 0.66mm and 0.52mm in the x, y and z dimensions
respectively for the monolithic-detector module in the proposed system. The latter
presented a POI estimation FWHM-resolution of 0.42mm, 0.41mm and 0.49mm in the
x, y and z dimensions respectively. The crystal depth, the number of crystal faces to
which a photosensor is coupled and the number of channels per photosensor were
optimised in order to reach the final proposed design.
date: 2023
id_scheme: DOI
id_number: 10.11588/heidok.00034131
ppn_swb: 1877228729
own_urn: urn:nbn:de:bsz:16-heidok-341319
date_accepted: 2023-12-04
advisor: HASH(0x558eaa7f4b18)
language: eng
bibsort: PAZOSCLEMEDEVELOPMEN
full_text_status: public
place_of_pub: Heidelberg
citation:   Pazos Clemens, Luis  (2023) Development and investigation of an integrated preclinical PET-OT system concept.  [Dissertation]     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/34131/1/PhD_THESIS_print.pdf