title: Development of radiofrequency coils for magnetic resonance-guided particle therapy
creator: Dietrich, Kilian Alexander
subject: 530
subject: 530 Physics
description: The aim of this work was to develop radiofrequency coils suitable for magnetic resonance (MR)-guided particle therapy. For two different MR systems (1.5 T, 0.25 T), a transmit/receive body coil and a receive-only calf coil were designed, constructed, optimized and built. The two coils are characterized by a very thin conductor (thickness:  35 μm) and high radiation transparency to enable precise particle therapy with simultaneous MR imaging. A negligible water equivalent thickness (WET) of the conductor (WET: 0.18−0.19 mm) was measured based on the dose distribution in a water column. In addition, both MR coils can be rotated, allowing flexible particle therapy with multi-angle irradiation. A high homogeneity of the transmit (body coil)  and receive (both coils) fields was confirmed in homogeneous phantoms for different rotation angles of the MR coils. The body coil also achieved sufficient transmit power efficiency (0.18−0.27 μT/√W) in the central slice for a complete rotation of the phantom. In terms of image quality, the signal-to-noise ratio (SNR) was measured in a homogeneous  phantom, where the body coil (SNR: 109−156) and the calf coil (SNR: 74−90) outperformed commercial coils. Furthermore, the functionality of the two coils was  demonstrated in an anthropomorphic phantom (body coil) and in vivo (calf coil).
date: 2024
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/34452/1/Dissertation.pdf
identifier: DOI:10.11588/heidok.00034452
identifier: urn:nbn:de:bsz:16-heidok-344529
identifier:   Dietrich, Kilian Alexander  (2024) Development of radiofrequency coils for magnetic resonance-guided particle therapy.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/34452/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng