TY  - GEN
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/35040/
ID  - heidok35040
CY  - Heidelberg
A1  - Graf, Akseli Petteri
N2  - Here, we investigated the long-term effects of different types of adolescent adversities; adolescent social isolation (ASI), social instability stress (SIS) and peer rejection (PR) in male and female rats, focusing their impact on social, anxiety-like and pain behaviors and the oxytocin system (study 1). We investigated the influence of timing of ASI (early or late) on adult behavior and additionally, we conducted oxytocin receptor (OTR) autoradiography in brain regions known to be involved in the aforementioned behaviors. We observed sex specific effects on both brain and behavior. 
First, female ASI (early and late) rats demonstrated a significant increase in OTR binding in the paraventricular nucleus of the hypothalamus (PVN) and paraventricular thalamus (PVT), while early ASI males demonstrated an increase in OTR binding in the central amygdala (CeA). ASI induced the largest behavioral changes in social recognition memory, social interactions and thermal pain sensitivity. In a subsequent validation experiment we optogentically evoked oxytoicin release in the PVT of EASI females were we observed the largest OTR changes following ASI. We attempted to validate whether their ASI associated alterations in social recognition and thermal pain sensitivity could be rescued by evoked oxytocin release.

In the second study we characterized the long-term behavioral outcomes of SIS in male and female Wistar rats (study 2). Here we found, that SIS resulted in decreased social interactions, heightened social approach, amplified exploratory behavior, and diminished anxiety-like behavior in both SIS male and female rats.

Finally, the thesis explored the long-term effects of our novel adolescent PR model on alcohol-seeking behavior in both sexes (study 3). We found that PR has sex-dependent effects on alcohol-seeking behavior, increasing alcohol cue-induced reinstatement in females, while decreasing in males. We found evidence of PR influencing circadian rhythms or sucrose consumption, suggesting PR deficits may be domain specific.
Y1  - 2024///
TI  - From adolescence to adulthood: characterizing the enduring consequences of adolescent adversities in rats
AV  - public
ER  -