<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Pupillary driven binocular interactions in retinal ganglion cells can encode binocular summation"^^ . "Binocular summation enhances visual discrimination of contrast and\r\nluminance during binocular viewing compared to monocular viewing. This improved binocular detection has mostly been described\r\nin human psychophysics experiments, and therefore the neural circuitry behind it remains unknown. The majority of other binocular\r\nprocesses, however, originate in the primary visual cortex (V1). Earlier\r\nparts of the image-forming visual pathway have not been thoroughly\r\nexplored as a potential source of binocular integration. While some\r\nlimited binocular interaction is known to occur in the lateral geniculate nucleus (LGN), retinal ganglion cells (RGC) are considered to be\r\ncompletely monocular.\r\nIn my PhD thesis, however, I used in vivo 2-photon calcium imaging to demonstrate that RGC boutons in the LGN can respond to\r\nstimulation of either eye. Furthermore, these binocular responses were\r\ncell-type-specific, with the stimulation of the opposite eye eliciting different responses in ON and OFF RGC boutons. To confirm that binocularity, observed in the RGC boutons was relevant in further visual\r\nprocessing I also recorded responses of the LGN boutons in the V1,\r\nshowing, that binocular information observed in the RGCs reaches\r\nthe cortex. Binocularity of the RGCs boutons in the LGN was surprising, as there are no known connections between the two retinas and\r\nno known axo-axonal synapses targeting RGC boutons in the LGN.\r\nHere, in collaboration with Pietro Micheli I showed, that binocularity,\r\nobserved in the RGC boutons didn’t originate locally, rather it was a\r\nresult of consensual pupillary constriction. While it has been known\r\nfor over a century that due to pupillary light reflex (PLR) pupils constrict consensually, allowing less light to enter the eye, the effect this\r\nchange of illumination has on visual processing has not been considered. In my thesis, however, we showed, that stimulating one eye\r\nleads to constriction of both pupils and a consequent visual response\r\nin the RGCs of the non-stimulated eye.\r\nTo understand the role of this novel form of binocularity in visual\r\nprocessing, I compared RGC responses to binocular and monocular\r\nstimulation and observed strong binocular facilitation only at low\r\ncontrasts, consistent with binocular summation being calculated on\r\nthe retina."^^ . "2025" . . . . . . . "Tjasa"^^ . "Lapanja"^^ . "Tjasa Lapanja"^^ . . . . . . "Pupillary driven binocular interactions in retinal ganglion cells can encode binocular summation (PDF)"^^ . . . "Pupillary driven binocular interactions in retinal ganglion cells can encode binocular summation (Other)"^^ . . . . . . "Pupillary driven binocular interactions in retinal ganglion cells can encode binocular summation (Other)"^^ . . . . . . "Pupillary driven binocular interactions in retinal ganglion cells can encode binocular summation (Other)"^^ . . . . . . "Pupillary driven binocular interactions in retinal ganglion cells can encode binocular summation (Other)"^^ . . . . . . "Pupillary driven binocular interactions in retinal ganglion cells can encode binocular summation (Other)"^^ . . . . . "HTML Summary of #35077 \n\nPupillary driven binocular interactions in retinal ganglion cells can encode binocular summation\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .