eprintid: 35191
rev_number: 13
eprint_status: archive
userid: 8326
dir: disk0/00/03/51/91
datestamp: 2024-08-02 05:13:02
lastmod: 2024-08-20 09:56:56
status_changed: 2024-08-02 05:13:02
type: doctoralThesis
metadata_visibility: show
creators_name: Muñoz Molina, Iván Domingo
title: Assessment of linear energy transfer and relative biological effectiveness in proton-beam therapy and ion-beam therapy with Al2O3:C,Mg detectors
subjects: ddc-530
divisions: i-130200
adv_faculty: af-13
abstract: In proton-beam therapy (PBT) and ion-beam therapy (IBT), treatment fields exhibit nonhomogeneous linear energy transfer (LET) distributions, which can cause variations in the relative biological effectiveness (RBE). Although these quantities are taken into account during treatment planning, there is currently no dedicated tool for the experimental assessment of LET and RBE in clinical practice. This lack of measurement tools poses a challenge to validating predictions from treatment planning systems, as is routinely done for absorbed dose. To address this gap, this thesis introduces novel methods for measuring LET and estimating RBE in PBT and IBT using aluminum oxide doped with carbon and magnesium (Al2O3:C,Mg) luminescent detectors. A method was developed to address variable sensitivity among individual fluorescent nuclear track detectors (FNTDs). Calibrations, enabling LET measurements in PBT and IBT, were established for both FNTDs and optically stimulated luminescence detectors (OSLDs). RBE models were integrated into the FNTDs workflow to predict RBE for protons and He-ions. Measurements to assess LET and RBE were conducted using proton and He-ion beams, and validated both in-vitro and in-silico. Finally, the developed techniques were applied during a measurement campaign aimed at identifying suitable detectors for LET measurements in PBT.
date: 2024
id_scheme: DOI
id_number: 10.11588/heidok.00035191
ppn_swb: 1899177736
own_urn: urn:nbn:de:bsz:16-heidok-351912
date_accepted: 2024-07-10
advisor: HASH(0x55a9a669ed58)
language: eng
bibsort: MUNOZMOLINASSESSMENT20240725
full_text_status: public
place_of_pub: Heidelberberg
citation:   Muñoz Molina, Iván Domingo  (2024) Assessment of linear energy transfer and relative biological effectiveness in proton-beam therapy and ion-beam therapy with Al2O3:C,Mg detectors.  [Dissertation]     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/35191/1/PhDThesis_IvanDMunoz_Final_ToPrint.pdf