<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "An end-to-end pipeline to study and\r\nmodel proton radiation-induced effects\r\nof the central nervous system as a\r\nfunction of dose and linear energy\r\ntransfer at the single-cell level in 3D"^^ . "Proton therapy is a promising form of brain radiotherapy due to its characteristic\r\nBragg peak profile sparing normal tissue. However, late side effects have been observed\r\nand the underlying mechanisms are not fully understood. An end-to-end pipeline\r\nwas first proposed to investigate late brain tissue-specific radiation-induced effects\r\nassociated with the central nervous system (CNS) as a function of dose and linear\r\nenergy transfer (LET) at the single-cell level in 3D for a well-established preclinical\r\nexperiment mimicking patient treatment. This pipeline includes Monte Carlo-based\r\ndose and LET calculation, target delivery verification, image processing tasks in-\r\ncluding preprocessing, local-affine multi-step registrations, a topology-preserving\r\nsegmentation, and analysis modules using 2-point density correlation functions, the\r\nRiemann elastic metric, and the CNS network size to measure compactness, shape\r\nand size heterogeneity. As a proof of principle, the pipeline was applied to investigate\r\nthe observed radiation-induced astrogliosis segmented with a Dice coefficient of 0.86,\r\nachieving a maximum dose and LET uncertainty of 2.5 Gy and 2 keV/mum. In\r\nconclusion, the analysis reveals that the process of astrogliosis can be considered as\r\na functional acting unit showing a radiation-induced late effect as a function of the\r\nbrain tissue type, dose and LET indicating a variable relative biological effectiveness."^^ . "2024" . . . . . . . "Marc Oliver"^^ . "Boucsein"^^ . "Marc Oliver Boucsein"^^ . . . . . . "An end-to-end pipeline to study and\r\nmodel proton radiation-induced effects\r\nof the central nervous system as a\r\nfunction of dose and linear energy\r\ntransfer at the single-cell level in 3D (PDF)"^^ . . . "PhD_Thesis_Marc_Boucsein.pdf"^^ . . . "An end-to-end pipeline to study and\r\nmodel proton radiation-induced effects\r\nof the central nervous system as a\r\nfunction of dose and linear energy\r\ntransfer at the single-cell level in 3D (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "An end-to-end pipeline to study and\r\nmodel proton radiation-induced effects\r\nof the central nervous system as a\r\nfunction of dose and linear energy\r\ntransfer at the single-cell level in 3D (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "An end-to-end pipeline to study and\r\nmodel proton radiation-induced effects\r\nof the central nervous system as a\r\nfunction of dose and linear energy\r\ntransfer at the single-cell level in 3D (Other)"^^ . . . . . . "preview.jpg"^^ . . . "An end-to-end pipeline to study and\r\nmodel proton radiation-induced effects\r\nof the central nervous system as a\r\nfunction of dose and linear energy\r\ntransfer at the single-cell level in 3D (Other)"^^ . . . . . . "medium.jpg"^^ . . . "An end-to-end pipeline to study and\r\nmodel proton radiation-induced effects\r\nof the central nervous system as a\r\nfunction of dose and linear energy\r\ntransfer at the single-cell level in 3D (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #35224 \n\nAn end-to-end pipeline to study and \nmodel proton radiation-induced effects \nof the central nervous system as a \nfunction of dose and linear energy \ntransfer at the single-cell level in 3D\n\n" . "text/html" . . . "530 Physik"@de . "530 Physics"@en . .