<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Long-Term Safety, Outcome, and Clinical Effects of Subcutaneous and Intravenous Treprostinil Treatment in Patients with Severe Chronic Pulmonary Arterial Hypertension"^^ . "Background: Current guidelines recommend treatment with parenteral prostacyclin analogs in patients with severe pulmonary arterial hypertension (PAH), who have insufficient response to treatment. Real-life data are sought to help physicians in treatment decisions and clinical care of patients. Objective: This study analyzed safety, clinical effects, and long-term outcomes of subcutaneous (sc) and/or intravenous (iv) treprostinil via different pump systems in consecutive patients with PAH. Methods: Thirty-seven patients with severe progressive PAH despite dual combination therapy (20 female, mean age: 52.3 ± 15 years, mean pulmonary vascular resistance: 12.1 ± 5.1 WU) were initiated with add-on treprostinil sc and were routinely clinically assessed. Changes in clinical parameters, adverse events, and outcome were analyzed retrospectively. Results: In 24 of 37 patients, treprostinil administration was continued iv via implantation of LENUS Pro® pump after 3 ± 1.3 months, 6 patients continued with sc therapy, and 7 discontinued treatment. After 3, 6, 9, and 12 months of treprostinil treatment, patients showed a significant improvement in mean 6-min walk distance and tricuspid annular plane systolic excursion compared to baseline. In 8 of the 24 patients, iv pumps required surgical revision. During a mean follow-up of 2.82 ± 1.95 years, 12 patients died, four received lung transplantation. Transplant-free survival after 1, 2, and 3 years was 85.7%, 69.2%, and 65.3%, respectively. Conclusion: sc treprostinil as add-on to double combination treatment significantly improved exercise capacity and right heart function. In most patients, treprostinil could be continued via more tolerable iv administration approach (LENUS Pro® pump), showing reasonable overall survival with respect to the severity of PAH."^^ . "2023-09" . . . "102" . "8" . . "Karger"^^ . . . "Respiration"^^ . . . "0025793114230356" . . . . . . . . . . . . . . . . . . . . . . . . . . . "Benjamin"^^ . "Egenlauf"^^ . "Benjamin Egenlauf"^^ . . "Panagiota"^^ . "Xanthouli"^^ . "Panagiota Xanthouli"^^ . . "Christian"^^ . "Nagel"^^ . "Christian Nagel"^^ . . "Nicola"^^ . "Benjamin"^^ . "Nicola Benjamin"^^ . . "Christina"^^ . "Eichstaedt"^^ . "Christina Eichstaedt"^^ . . "Alberto M."^^ . "Marra"^^ . "Alberto M. Marra"^^ . . "Ekkehard"^^ . "Grünig"^^ . "Ekkehard Grünig"^^ . . "Satenik"^^ . "Harutyunova"^^ . "Satenik Harutyunova"^^ . . . . . . "Long-Term Safety, Outcome, and Clinical Effects of Subcutaneous and Intravenous Treprostinil Treatment in Patients with Severe Chronic Pulmonary Arterial Hypertension (PDF)"^^ . . . "000531169.pdf"^^ . . . "Long-Term Safety, Outcome, and Clinical Effects of Subcutaneous and Intravenous Treprostinil Treatment in Patients with Severe Chronic Pulmonary Arterial Hypertension (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Long-Term Safety, Outcome, and Clinical Effects of Subcutaneous and Intravenous Treprostinil Treatment in Patients with Severe Chronic Pulmonary Arterial Hypertension (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Long-Term Safety, Outcome, and Clinical Effects of Subcutaneous and Intravenous Treprostinil Treatment in Patients with Severe Chronic Pulmonary Arterial Hypertension (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Long-Term Safety, Outcome, and Clinical Effects of Subcutaneous and Intravenous Treprostinil Treatment in Patients with Severe Chronic Pulmonary Arterial Hypertension (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Long-Term Safety, Outcome, and Clinical Effects of Subcutaneous and Intravenous Treprostinil Treatment in Patients with Severe Chronic Pulmonary Arterial Hypertension (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #35530 \n\nLong-Term Safety, Outcome, and Clinical Effects of Subcutaneous and Intravenous Treprostinil Treatment in Patients with Severe Chronic Pulmonary Arterial Hypertension\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .