title: Towards the Clinical Application of Helium Ions at the Heidelberg Ion-Beam Therapy Center - Physical and Clinical Aspects
creator: Besuglow, Judith
subject: ddc-500
subject: 500 Natural sciences and mathematics
subject: ddc-530
subject: 530 Physics
subject: ddc-570
subject: 570 Life sciences
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Long before the invention of current standard modalities such as intensity-modulated radiotherapy, helium ions were already incorporated clinically in the 1980s at the Lawrence Berkeley National Lab. At the onset of this research, although helium ion beams are available for pre-clinical experiments at the Heidelberg Ion-Beam Therapy Center (HIT), a clinically validated Treatment Planning System (TPS) with a refined dose calculation model was still warranted for a safe clinical application. This doctoral thesis reports and outlines a comprehensive database of beam properties created to this end. This database includes the geometric dose distribution for each of the available 255 initial beam energies at HIT, as well as measurements of depth and lateral dose profiles measured and recreations thereof via a Monte Carlo beam model. Moreover, the thereby prepared beam model allowed for the investigation on the influence of the dose received by a patient in the presence of any variations. These efforts significantly contributed to the successful commissioning of the first commercial TPS for helium ion beams, enabling the first patient treatment. Finally, to correctly assess the biological damage induced by this new radiation modality, a retrospective analysis of a past clinical trial was carried out, evaluating models of relative biological effectiveness for protons and carbon ions regarding their predictive capability for the tumor control of prostate cancer.
date: 2024
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserver/35793/13/Dissertation_JudithBesuglow_druck.pdf
identifier: DOI:10.11588/heidok.00035793
identifier: urn:nbn:de:bsz:16-heidok-357939
identifier:   Besuglow, Judith  (2024) Towards the Clinical Application of Helium Ions at the Heidelberg Ion-Beam Therapy Center - Physical and Clinical Aspects.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/35793/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng