<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Maladaptation diseases as disorders of goal state integration and intraorganismal individuation"^^ . "The present work introduces the hypothesis that various human maladaptation diseases including addiction, cancer, autoimmunity, fibrosis, depression, chronic pain and post-traumatic stress disorder share a universal functional pattern in that they are all caused by defects in goal state integration of physiological subsystems into whole-organism goal states and by the resulting emergence of new levels of individuality within the organism. In this framework, a general mechanism in ontogenetic maladaptation is the intraorganismal individuation of subsystems via physiological adaptation mechanisms, which results in these systems becoming uncoupled from the rest of the organism and pursuing a hyperoptimization of their own goals at the cost of whole organism health. A central mechanism for mediating continued dysfunction in these disorders is the formation and maintenance of maladaptive memories. A potential universal therapeutic principle for maladaptation disorders is to provide physiological integration pressure to force subsystems to integrate back into the functional organization of the whole organism."^^ . "2025" . . . . . . . "Thomas"^^ . "Lissek"^^ . "Thomas Lissek"^^ . . . . . . "Maladaptation diseases as disorders of goal state integration and intraorganismal individuation (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Maladaptation diseases as disorders of goal state integration and intraorganismal individuation (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Maladaptation diseases as disorders of goal state integration and intraorganismal individuation (Other)"^^ . . . . . . "small.jpg"^^ . . . "Maladaptation diseases as disorders of goal state integration and intraorganismal individuation (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Maladaptation diseases as disorders of goal state integration and intraorganismal individuation (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Maladaptation diseases as disorders of goal state integration and intraorganismal individuation (PDF)"^^ . . . "Lissek_Maladaptation_disorders_2025.pdf"^^ . . "HTML Summary of #36145 \n\nMaladaptation diseases as disorders of goal state integration and intraorganismal individuation\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .