eprintid: 36145
rev_number: 15
eprint_status: archive
userid: 7830
dir: disk0/00/03/61/45
datestamp: 2025-02-26 09:38:21
lastmod: 2025-04-10 14:19:44
status_changed: 2025-02-26 09:38:21
type: preprint
metadata_visibility: show
creators_name: Lissek, Thomas
title: Maladaptation diseases as disorders of goal state integration and intraorganismal individuation
subjects: ddc-610
divisions: i-712000
abstract: The present work introduces the hypothesis that various human maladaptation diseases including addiction, cancer, autoimmunity, fibrosis, depression, chronic pain and post-traumatic stress disorder share a universal functional pattern in that they are all caused by defects in goal state integration of physiological subsystems into whole-organism goal states and by the resulting emergence of new levels of individuality within the organism. In this framework, a general mechanism in ontogenetic maladaptation is the intraorganismal individuation of subsystems via physiological adaptation mechanisms, which results in these systems becoming uncoupled from the rest of the organism and pursuing a hyperoptimization of their own goals at the cost of whole organism health. A central mechanism for mediating continued dysfunction in these disorders is the formation and maintenance of maladaptive memories. A potential universal therapeutic principle for maladaptation disorders is to provide physiological integration pressure to force subsystems to integrate back into the functional organization of the whole organism.
date: 2025
id_scheme: DOI
id_number: 10.11588/heidok.00036145
ppn_swb: 1922114987
own_urn: urn:nbn:de:bsz:16-heidok-361453
language: eng
bibsort: LISSEKTHOMMALADAPTAT2025
full_text_status: public
place_of_pub: Heidelberg
citation:   Lissek, Thomas  (2025) Maladaptation diseases as disorders of goal state integration and intraorganismal individuation.  [Preprint]     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/36145/7/Lissek_Maladaptation_disorders_2025.pdf