eprintid: 36326
rev_number: 11
eprint_status: archive
userid: 5878
dir: disk0/00/03/63/26
datestamp: 2025-04-01 09:04:18
lastmod: 2025-04-01 09:04:57
status_changed: 2025-04-01 09:04:18
type: article
metadata_visibility: show
creators_name: Kruse, Marianne
creators_name: Plettig, Philip
creators_name: Josuttis, David
creators_name: Guembel, Denis
creators_name: Guethoff, Claas
creators_name: Hartmann, Bernd
creators_name: Kuepper, Simon
creators_name: Gebhardt, Volker
creators_name: Schmittner, Marc Dominik
title: Stroke Volume and Stroke Volume Variation, but not Cardiac Index Is Associated With Survival of Majorly Burned Patients in Early Burn Shock
ispublished: pub
subjects: ddc-610
divisions: i-61600
note: Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich. *** This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
abstract: Adequate fluid therapy is crucial to maintain organ function after burn trauma. Major burns lead to a systemic response with fluid loss and cardiac dysfunction. To guide fluid therapy, measurement of cardiac pre- and afterload is helpful. Whereas cardiac function is usually measured after admission to intensive care unit (ICU), in this study, hemodynamic monitoring was performed directly after arrival at hospital. We conducted a prospective cohort study with inclusion of 19 patients (male/female 13/6, 55 ± 18 years, mean total body surface area 36 ± 19%). Arterial waveform analysis (PulsioFlexProAqt ® , Getinge) was implemented immediately after admission to hospital to measure cardiac pre- and afterload and to guide resuscitation therapy. Cardiac parameters 3.75 (2.67-6.0) h after trauma were normal regarding cardiac index (3.45 ± 0.82) L/min/m², systemic vascular resistance index (1749 ± 533) dyn sec/cm 5 m 2 , and stroke volume (SV; 80 ± 20) mL. Stroke volume variation (SVV) was increased (21 ± 7) % and associated with mortality (mean SVV survivors vs nonsurvivors 18.92 (±6.37) % vs 27.6 (±5.68) %, P = .017). Stroke volume was associated with mortality at the time of ICU-admission (mean SV survivors vs nonsurvivors 90 (±20) mL vs 50 (±0) mL, P = .004). Changes after volume challenge were significant for SVV (24 ± 9 vs19 ± 8%, P = .01) and SV (68 ± 24 vs 76 ± 26 mL, P = .03). We described association of SVV and SV with survival of severely burned patients in an observational study. This indicates high valence of those parameters in the early postburn period. The use of an autocalibrated device enables a very early monitoring of parameters relevant to burn shock survival.
date: 2025
date_type: published
publisher: Sage
id_scheme: DOI
id_number: 10.11588/heidok.00036326
official_url: https://doi.org/10.1177/08850666241268470
own_urn: urn:nbn:de:bsz:16-heidok-363264
language: eng
bibsort: KRUSEMARIASTROKEVOLU20250201
full_text_status: restricted
publication: Journal of Intensive Care Medicine
volume: 40
number: 2
place_of_pub: Thousand Oaks, Calif.
pagerange: 164-171
pages: 8
issn: 0885-0666 (Druck-Ausg.); 1525-1489 (Online-Ausg.)
edition: Zweitveröffentlichung
citation:   Kruse, Marianne ; Plettig, Philip ; Josuttis, David ; Guembel, Denis ; Guethoff, Claas ; Hartmann, Bernd ; Kuepper, Simon ; Gebhardt, Volker ; Schmittner, Marc Dominik  (2025) Stroke Volume and Stroke Volume Variation, but not Cardiac Index Is Associated With Survival of Majorly Burned Patients in Early Burn Shock.  Journal of Intensive Care Medicine, 40 (2).  pp. 164-171.  ISSN 0885-0666 (Druck-Ausg.); 1525-1489 (Online-Ausg.)     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/36326/1/10.1177_08850666241268470.pdf