title: Mask Continuous Positive Airway Pressure Increases Diaphragm Thickening Fraction in Healthy Subjects creator: Lindner, Simon creator: Teichert, Jan creator: Hoermann, Clara creator: Michels, Julia D. creator: Herth, Felix J.F. creator: Duerschmied, Daniel creator: Britsch, Simone subject: ddc-610 subject: 610 Medical sciences Medicine description: Introduction: The most widespread treatment for obstructive sleep apnoea and obesity hypoventilation syndrome is continuous positive airway pressure (CPAP). The addition of inspiratory support is a potential alternative. This is a physiological study to determine the effect of CPAP and inspiratory support pressure on respiratory effort measured by diaphragm thickening fraction (DTF) in healthy volunteers. Methods: DTF was measured in spontaneously breathing, healthy volunteers during 4 phases: (I) without connection to a ventilator, (II) on a ventilator without any applied pressures, (III) with a CPAP of 5 cmH2O, and (IV) with an additional inspiratory support pressure of 5 cmH2O. Results: Twenty-nine individuals agreed to participate. DTF was similar during the first two phases (32 ± 13% and 35 ± 22%). A considerable increase in DTF to 51 ± 21% was noted in phase III. The introduction of inspiratory support pressure during phase IV led to a reduction in DTF back to 36 ± 23% (p < 0.001). Tidal volume and minute ventilation were both slightly higher in phase IV compared to phase III. Conclusion: CPAP without inspiratory support pressure increases respiratory effort measured by DTF in healthy subjects. Further research is required to investigate this phenomenon in a clinical setting. publisher: Karger date: 2024 type: Article type: info:eu-repo/semantics/article type: NonPeerReviewed format: application/pdf identifier: https://archiv.ub.uni-heidelberg.de/volltextserver/36564/1/RES535990.pdf identifier: DOI:10.11588/heidok.00036564 identifier: https://doi.org/10.1159/000535990 identifier: urn:nbn:de:bsz:16-heidok-365645 identifier: Lindner, Simon ; Teichert, Jan ; Hoermann, Clara ; Michels, Julia D. ; Herth, Felix J.F. ; Duerschmied, Daniel ; Britsch, Simone (2024) Mask Continuous Positive Airway Pressure Increases Diaphragm Thickening Fraction in Healthy Subjects. Respiration, 103 (2). pp. 100-104. ISSN 0025-7931 (Druck-Ausg.); 1423-0356 (Online-Ausg.) relation: https://archiv.ub.uni-heidelberg.de/volltextserver/36564/ rights: info:eu-repo/semantics/openAccess rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html language: eng