title: Mask Continuous Positive Airway Pressure Increases Diaphragm Thickening Fraction in Healthy Subjects
creator: Lindner, Simon
creator: Teichert, Jan
creator: Hoermann, Clara
creator: Michels, Julia D.
creator: Herth, Felix J.F.
creator: Duerschmied, Daniel
creator: Britsch, Simone
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Introduction: The most widespread treatment for obstructive sleep apnoea and obesity hypoventilation syndrome is continuous positive airway pressure (CPAP). The addition of inspiratory support is a potential alternative. This is a physiological study to determine the effect of CPAP and inspiratory support pressure on respiratory effort measured by diaphragm thickening fraction (DTF) in healthy volunteers. Methods: DTF was measured in spontaneously breathing, healthy volunteers during 4 phases: (I) without connection to a ventilator, (II) on a ventilator without any applied pressures, (III) with a CPAP of 5 cmH2O, and (IV) with an additional inspiratory support pressure of 5 cmH2O. Results: Twenty-nine individuals agreed to participate. DTF was similar during the first two phases (32 ± 13% and 35 ± 22%). A considerable increase in DTF to 51 ± 21% was noted in phase III. The introduction of inspiratory support pressure during phase IV led to a reduction in DTF back to 36 ± 23% (p < 0.001). Tidal volume and minute ventilation were both slightly higher in phase IV compared to phase III. Conclusion: CPAP without inspiratory support pressure increases respiratory effort measured by DTF in healthy subjects. Further research is required to investigate this phenomenon in a clinical setting.
publisher: Karger
date: 2024
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserver/36564/1/RES535990.pdf
identifier: DOI:10.11588/heidok.00036564
identifier: https://doi.org/10.1159/000535990
identifier: urn:nbn:de:bsz:16-heidok-365645
identifier:   Lindner, Simon ; Teichert, Jan ; Hoermann, Clara ; Michels, Julia D. ; Herth, Felix J.F. ; Duerschmied, Daniel ; Britsch, Simone  (2024) Mask Continuous Positive Airway Pressure Increases Diaphragm Thickening Fraction in Healthy Subjects.  Respiration, 103 (2).  pp. 100-104.  ISSN 0025-7931 (Druck-Ausg.); 1423-0356 (Online-Ausg.)     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/36564/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng